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Polr2I RNA polymerase II subunit I [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41741, updated on 4-Apr-2024

Summary

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Official Symbol
Polr2Iprovided by FlyBase
Official Full Name
RNA polymerase II subunit Iprovided by FlyBase
Primary source
FLYBASE:FBgn0004855
Locus tag
Dmel_CG3284
See related
AllianceGenome:FB:FBgn0004855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3284; Dmel\CG3284; dRPB9; H5; l(3)88Be; l(3)Z23; pol II; Pol II; polII; PolII; RNA pol II; RNA Pol II; RNA polII; RNAP; RNAP II; RNApolII; Rpb9; RPB9; RpII15; RPII15; RpII215
Summary
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Involved in mitotic cell cycle. Located in nucleus. Part of RNA polymerase II, core complex. Is expressed in organism. Orthologous to human POLR2I (RNA polymerase II subunit I). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
88B3-88B3; 3-55 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14309089..14310178)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10134811..10135900)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene red Malpighian tubules Neighboring gene Intraflagellar transport 54 Neighboring gene suppressor of Hairy wing Neighboring gene uncharacterized protein Neighboring gene Corazonin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RPII15 codes for the M(r) 15,000 subunit 9 of Drosophila melanogaster RNA polymerase II. Liu Z, et al. FEBS Lett, 1993 Nov 29. PMID 8243669
  2. RNA polymerase II subunits exhibit a broad distribution of macromolecular assembly states in the interchromatin space of cell nuclei. Tycon MA, et al. J Phys Chem B, 2014 Jan 16. PMID 24354435
  3. Invading viral DNA triggers dsRNA synthesis by RNA polymerase II to activate antiviral RNA interference in Drosophila. de Faria IJS, et al. Cell Rep, 2022 Jun 21. PMID 35732126, Free PMC Article
  4. Kinetics of promoter Pol II on Hsp70 reveal stable pausing and key insights into its regulation. Buckley MS, et al. Genes Dev, 2014 Jan 1. PMID 24395245, Free PMC Article
  5. Determination of Coxiella burnetii rpoB sequence and its use for phylogenetic analysis. Mollet C, et al. Gene, 1998 Jan 19. PMID 9511749

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle HMP PubMed 
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription-coupled nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase II, core complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA polymerase II subunit I
Names
CG3284-PA
CG3284-PB
CG3284-PC
Polr2I-PA
Polr2I-PB
Polr2I-PC
RNA pol II
RNA polymerase II
RNA polymerase II 15kd subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14309089..14310178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300397.1 → NP_001287326.1  RNA polymerase II subunit I, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287326.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36958, Q9VFK8
    UniProtKB/TrEMBL
    A0A0B4K652, B7FNR6
    Conserved Domains (2) summary
    COG1594
    Location:18 → 129
    RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
    cd10508
    Location:78 → 128
    Zn-ribbon_RPB9; C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II

  2. NM_169575.3 → NP_731898.1  RNA polymerase II subunit I, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731898.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36958, Q9VFK8
    UniProtKB/TrEMBL
    A0A0B4K652, B7FNR6
    Related
    FBpp0082384
    Conserved Domains (2) summary
    COG1594
    Location:18 → 129
    RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
    cd10508
    Location:78 → 128
    Zn-ribbon_RPB9; C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II

  3. NM_001260170.2 → NP_001247099.1  RNA polymerase II subunit I, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247099.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36958, Q9VFK8
    UniProtKB/TrEMBL
    A0A0B4K652, B7FNR6
    Conserved Domains (2) summary
    COG1594
    Location:18 → 129
    RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
    cd10508
    Location:78 → 128
    Zn-ribbon_RPB9; C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K652 A0A0B4K652
P36958.2 P36958

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