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Polr2B RNA polymerase II subunit B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41721, updated on 27-Mar-2024

Summary

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Official Symbol
Polr2Bprovided by FlyBase
Official Full Name
RNA polymerase II subunit Bprovided by FlyBase
Primary source
FLYBASE:FBgn0262955
Locus tag
Dmel_CG3180
See related
AllianceGenome:FB:FBgn0262955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3180; Dmel\CG3180; DmRP140; H5; II; l(3)RplII140; pol II; Pol II; Pol IIc; polII; PolII; PolIIc; RNA pol II; RNA Pol II; RNA Pol II 140; RNA Pol IIc; RNA polII; RNAP; RNAP II; RNApolII; RP140; Rpb2; RPB2; RPB2_DROME; RpII140; RPII140; rpII140/wimp; RpII140[wimp]; RpIl140; Rpll140; wimp
Summary
Predicted to enable DNA binding activity and ribonucleoside binding activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in transcription by RNA polymerase II. Part of RNA polymerase II, core complex. Is expressed in several structures, including embryonic brain; embryonic/larval midgut; embryonic/larval nervous system; and extended germ band embryo. Orthologous to human POLR2B (RNA polymerase II subunit B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
88A9-88A9; 3-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14125791..14130111)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9951513..9955833)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Abelson interacting protein Neighboring gene twinfilin Neighboring gene upstream of RpII140 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a nucleic acid-binding region within the largest subunit of Drosophila melanogaster RNA polymerase II. Kontermann RE, et al. Protein Sci, 1993 Feb. PMID 8443600, Free PMC Article
  2. Identifying a transcription factor interaction site on RNA polymerase II. Skantar AM, et al. Gene Expr, 1995. PMID 7488860, Free PMC Article
  3. RNA polymerase II of Drosophila. Relation of its 140,000 Mr subunit to the beta subunit of Escherichia coli RNA polymerase. Falkenburg D, et al. J Mol Biol, 1987 Jun 20. PMID 3116266
  4. Analysis of the promoter region of the housekeeping gene DmRP140 by sequence comparison of Drosophila melanogaster and Drosophila virilis. Sitzler S, et al. Gene, 1991 Sep 15. PMID 1937028
  5. Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing. Pérez-Lluch S, et al. Nucleic Acids Res, 2011 Jun. PMID 21310711, Free PMC Article

See all (165) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity NAS
Non-traceable Author Statement
more info
 PubMed 
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ribonucleoside binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase II, core complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of RNA polymerase II, core complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
RNA polymerase II subunit B
Names
150kDa polypeptide
CG3180-PA
CG3180-PB
Pol II
Polr2B-PA
Polr2B-PB
RNA pol II second largest subunit
RNA polymerase II
RNA polymerase II 140 kD subunit
RNA polymerase II 140kD subunit
RNA polymerase II second largest subunit
RNA polymerase IIc
RNA polymerase subunit IIc
RNA polymeraseII-140 kd subunit
Rpb2
subunit IIc of RNA Pol II
wimp
NP_001287323.1
NP_476706.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14125791..14130111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300394.1 → NP_001287323.1  RNA polymerase II subunit B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287323.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08266, Q04155, Q95027, Q9VFM7
    UniProtKB/TrEMBL
    A0A0B4LI86
    Conserved Domains (1) summary
    PRK08565
    Location:28 → 1176
    PRK08565; DNA-directed RNA polymerase subunit B; Provisional

  2. NM_057358.4 → NP_476706.1  RNA polymerase II subunit B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476706.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08266, Q04155, Q95027, Q9VFM7
    UniProtKB/TrEMBL
    A0A0B4LI86
    Related
    FBpp0082353
    Conserved Domains (1) summary
    PRK08565
    Location:28 → 1176
    PRK08565; DNA-directed RNA polymerase subunit B; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LI86 A0A0B4LI86
P08266.2 P08266

Gene LinkOut

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