SOCS1 suppressor of cytokine signaling 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SOCS1provided by CGNC
Full Name: suppressor of cytokine signaling 1provided by CGNC
Primary source: CGNC:5410
See related: Ensembl:ENSGALG00010019269
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	14	NC_052545.1 (8952774..8955462)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	14	NC_052586.1 (8949681..8952369)

Chromosome 14 - NC_052545.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Basal expression levels of chSOCS1 are 16-fold higher in DF-1 than in its progenitor primary chicken embryo fibroblasts (CEFs). The chSOCS1 "SOCS box" domain is not essential for the inhibition of cytokine-induced JAK/STAT signalling activation in DF-1. Overexpression of SOCS1 in chIFN-alpha-stimulated DF-1 led to a relative decrease in expression of interferon-stimulated genes and increased viral yield in response to ...
Title: Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: suppressor of cytokine signaling 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001137648.1 → NP_001131120.1 suppressor of cytokine signaling 1

See identical proteins and their annotated locations for NP_001131120.1

Status: PROVISIONAL

Source sequence(s)

EF554725

UniProtKB/TrEMBL

B6RCQ2

Conserved Domains (2) summary

cd10382
Location:64 → 161

SH2_SOCS1; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03735
Location:165 → 207

SOCS_SOCS1; SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

8952774..8955462

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015294233.4 → XP_015149719.1 suppressor of cytokine signaling 1 isoform X1

UniProtKB/TrEMBL

B6RCQ2

Related

ENSGALP00010027754.1, ENSGALT00010046596.1

Conserved Domains (2) summary

cd10382
Location:64 → 161

SH2_SOCS1; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03735
Location:165 → 207

SOCS_SOCS1; SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the ...
XM_046900653.1 → XP_046756609.1 suppressor of cytokine signaling 1 isoform X1

UniProtKB/TrEMBL

B6RCQ2

Related

ENSGALP00010027751.1, ENSGALT00010046593.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

8949681..8952369

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046927472.1 → XP_046783428.1 suppressor of cytokine signaling 1 isoform X1

UniProtKB/TrEMBL

B6RCQ2
XM_046927473.1 → XP_046783429.1 suppressor of cytokine signaling 1 isoform X1

UniProtKB/TrEMBL

B6RCQ2