PLK1 polo like kinase 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: PLK1provided by CGNC
Full Name: polo like kinase 1provided by CGNC
Primary source: CGNC:4585
See related: Ensembl:ENSGALG00010017105
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	14	NC_052545.1 (6905711..6911202)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	14	NC_052586.1 (6901598..6907094)

Chromosome 14 - NC_052545.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p17 suppresses both CDK1 and Plk1functions, disrupts vimentin phosphorylation, causes G2/M cell cycle arrest and thus benefits virus replication.
Title: Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cytokinesis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase PLK1

NP_001025810.2

EC 2.7.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030639.2 → NP_001025810.2 serine/threonine-protein kinase PLK1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000257

UniProtKB/TrEMBL

F1NCX7, Q5ZJ36

Related

ENSGALP00010024174.1, ENSGALT00010041287.1

Conserved Domains (3) summary

cd13117
Location:500 → 581

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:398 → 485

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14187
Location:35 → 299

STKc_PLK1; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1