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NR3C1 nuclear receptor subfamily 3 group C member 1 [ Gallus gallus (chicken) ]

Gene ID: 416343, updated on 5-Mar-2024

Summary

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Symbol
NR3C1provided by CGNC
Full Name
nuclear receptor subfamily 3 group C member 1provided by CGNC
Primary source
CGNC:5586
See related
Ensembl:ENSGALG00010016758
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
GR
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (16997653..17099929, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (17009845..17112096, complement)

Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121106695 Neighboring gene fibroblast growth factor 1 Neighboring gene Rho GTPase activating protein 26 Neighboring gene microRNA 6588 Neighboring gene uncharacterized LOC112533400 Neighboring gene Yip1 domain family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene expression of hepatic glucocorticoid receptor NR3C1 and correlation with plasmatic corticosterone in Italian chickens. Marelli SP, et al. Anim Biotechnol, 2010 Apr. PMID 20379891
  2. Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extrapituitary tissues. Kwok AH, et al. Poult Sci, 2007 Feb. PMID 17234861
  3. Cloning of partial cDNAs for the chicken glucocorticoid and mineralocorticoid receptors and characterization of mRNA levels in the anterior pituitary gland during chick embryonic development. Porter TE, et al. Domest Anim Endocrinol, 2007 Aug. PMID 16787734
  4. Pituitary expression of type I and type II glucocorticoid receptors during chicken embryonic development and their involvement in growth hormone cell differentiation. Bossis I, et al. Endocrinology, 2004 Jul. PMID 15070856
  5. Functional characterization of chicken glucocorticoid and mineralocorticoid receptors. Proszkowiec-Weglarz M, et al. Am J Physiol Regul Integr Comp Physiol, 2010 May. PMID 20181832

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cortisone and aldosterone induced cGR- and cMR-driven transcriptional activity in a dose-dependent manner; Each receptor responded to both steroids, but cMR transcriptional activity was induced by lower levels of CORT and ALDO than cGR
    Title: Functional characterization of chicken glucocorticoid and mineralocorticoid receptors.
  2. The breed-related expression of NR3C1 and corticosterone blood levels in 3 Italian chicken breeds are reported.
    Title: Gene expression of hepatic glucocorticoid receptor NR3C1 and correlation with plasmatic corticosterone in Italian chickens.
  3. GR protein was detected in pituitary extracts as early as embryonic d 8, whereas MR protein was readily detectable only around d 12.
    Title: Pituitary expression of type I and type II glucocorticoid receptors during chicken embryonic development and their involvement in growth hormone cell differentiation.
  4. The cloning and characterization of GR in chickens is reported.
    Title: Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extrapituitary tissues.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear glucocorticoid receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucocorticoid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glucocorticoid receptor
Names
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037826.1 → NP_001032915.1  glucocorticoid receptor

    See identical proteins and their annotated locations for NP_001032915.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ227738
    UniProtKB/TrEMBL
    Q38HX7
    Related
    ENSGALP00010023444.1, ENSGALT00010040409.1
    Conserved Domains (3) summary
    cd07076
    Location:526 → 772
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:412 → 489
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:28 → 397
    GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    16997653..17099929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046900387.1 → XP_046756343.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    A0A1D5PRD7

  2. XM_046900388.1 → XP_046756344.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    A0A1D5PRD7

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    17009845..17112096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046927040.1 → XP_046782996.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    A0A1D5PRD7

  2. XM_046927041.1 → XP_046782997.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    A0A1D5PRD7
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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