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PLCG2 phospholipase C gamma 2 [ Gallus gallus (chicken) ]

Gene ID: 415805, updated on 5-Mar-2024

Summary

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Symbol
PLCG2provided by CGNC
Full Name
phospholipase C gamma 2provided by CGNC
Primary source
CGNC:4062
See related
Ensembl:ENSGALG00010007393
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
35
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 11 NC_052542.1 (15318292..15376195)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 11 NC_052583.1 (15643995..15723320)

Chromosome 11 - NC_052542.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054317 Neighboring gene c-Maf inducing protein Neighboring gene uncharacterized LOC124417150 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling. Qin S, et al. Biochemistry, 2001 Jul 10. PMID 11434777
  2. Cloning and functional characterization of chicken stem cell antigen 2. Mao W, et al. Dev Comp Immunol, 2010 Mar. PMID 19945479

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Names
phospholipase C, gamma 2 (phosphatidylinositol-specific)
XP_004944315.2
XP_025010053.2
XP_040537265.1
XP_040537266.1
XP_040537267.1
XP_040537268.1
XP_040563108.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15318292..15376195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025154285.3 → XP_025010053.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XNH9, A0A8V0XNI4
    Related
    ENSGALP00010009747.1, ENSGALT00010017633.1
    Conserved Domains (8) summary
    cd00275
    Location:1114 → 1240
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd09932
    Location:695 → 798
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:580 → 681
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:826 → 880
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13362
    Location:76 → 192
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:198 → 351
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:364 → 511
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:890 → 962
    PH-like; Pleckstrin homology-like domain

  2. XM_004944258.5 → XP_004944315.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XUR6, A0A8V0Y0I2
    Related
    ENSGALP00010009744.1, ENSGALT00010017630.1
    Conserved Domains (8) summary
    cd00275
    Location:1085 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd09932
    Location:666 → 769
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:551 → 652
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:797 → 851
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13362
    Location:47 → 163
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:169 → 322
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:335 → 482
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:861 → 933
    PH-like; Pleckstrin homology-like domain

  3. XM_040707174.2 → XP_040563108.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X3

    UniProtKB/TrEMBL
    A0A1D5PHP4, A0A8V0Y0I2
    Related
    ENSGALP00010009743.1, ENSGALT00010017628.1
    Conserved Domains (8) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd09932
    Location:642 → 745
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 628
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13362
    Location:23 → 139
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:311 → 458
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:837 → 909
    PH-like; Pleckstrin homology-like domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    15643995..15723320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040681334.2 → XP_040537268.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y0I2
    Conserved Domains (8) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd09932
    Location:642 → 745
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 628
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13362
    Location:23 → 139
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:311 → 458
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:837 → 909
    PH-like; Pleckstrin homology-like domain

  2. XM_040681333.2 → XP_040537267.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y0I2
    Conserved Domains (8) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd09932
    Location:642 → 745
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 628
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13362
    Location:23 → 139
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:311 → 458
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:837 → 909
    PH-like; Pleckstrin homology-like domain

  3. XM_040681332.2 → XP_040537266.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y0I2
    Conserved Domains (8) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd09932
    Location:642 → 745
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 628
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13362
    Location:23 → 139
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:311 → 458
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:837 → 909
    PH-like; Pleckstrin homology-like domain

  4. XM_040681331.2 → XP_040537265.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y0I2
    Conserved Domains (8) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd09932
    Location:642 → 745
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 628
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13362
    Location:23 → 139
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:311 → 458
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:837 → 909
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
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