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IQGAP1 IQ motif containing GTPase activating protein 1 [ Gallus gallus (chicken) ]

Gene ID: 415591, updated on 5-Mar-2024

Summary

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Official Symbol
IQGAP1provided by CGNC
Official Full Name
IQ motif containing GTPase activating protein 1provided by CGNC
Primary source
CGNC:107049120
See related
Ensembl:ENSGALG00010000047
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
38
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (20332964..20383461)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (20198379..20248896)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene tumor protein p53 binding protein 1 Neighboring gene tubulin gamma complex associated protein 4 Neighboring gene uncharacterized LOC107054220 Neighboring gene uncharacterized LOC121111627 Neighboring gene uncharacterized LOC107053610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alteration of gene expression of IQGAP1 and Rho-family GTPases in the cadmium-induced ventral body wall defects in the chick model. Doi T, et al. Reprod Toxicol, 2011 Jul. PMID 21679763
  2. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cadmium altered gene expression of IQGAP1 and Rho-family GTPases in ventral body wall defects in the chick model.
    Title: Alteration of gene expression of IQGAP1 and Rho-family GTPases in the cadmium-induced ventral body wall defects in the chick model.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ras GTPase-activating-like protein IQGAP1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    20332964..20383461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_413959.8 → XP_413959.4  ras GTPase-activating-like protein IQGAP1

    UniProtKB/TrEMBL
    A0A1D5PIZ8, A0A8V0X244
    Related
    ENSGALP00010000043.1, ENSGALT00010000067.1
    Conserved Domains (5) summary
    cd05133
    Location:1004 → 1383
    RasGAP_IQGAP1; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 1
    COG5022
    Location:699 → 974
    COG5022; Myosin heavy chain [General function prediction only]
    COG5261
    Location:877 → 1658
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    cd00201
    Location:684 → 713
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl00030
    Location:13 → 168
    CH_SF; calponin homology (CH) domain superfamily

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    20198379..20248896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040680436.2 → XP_040536370.1  ras GTPase-activating-like protein IQGAP1

    UniProtKB/TrEMBL
    A0A1D5PIZ8, A0A8V0X244
    Conserved Domains (5) summary
    cd05133
    Location:1004 → 1383
    RasGAP_IQGAP1; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 1
    COG5022
    Location:699 → 974
    COG5022; Myosin heavy chain [General function prediction only]
    COG5261
    Location:877 → 1658
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    cd00201
    Location:684 → 713
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl00030
    Location:13 → 168
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein
Heading Accession and Version

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