Prosalpha2 Proteasome alpha2 subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prosalpha2provided by FlyBase
Official Full Name: Proteasome alpha2 subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0086134
Locus tag: Dmel_CG5266
See related: AllianceGenome:FB:FBgn0086134
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 153303_at; 20S-(a); 20S-alpha; alpha-2; Alpha-2; alpha2; alpha2_dm; CG5266; dalpha2; Dmel\CG5266; PRC3; Pros alpha2; PROS Dm25; PROS-Dm25g; pros25; Pros25; prosalpha2; Prot. 25 Kda; PSA2_DROME; Su(DTS); Su(DTS)-1
Summary: Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head; adult heart; germline cell; and organism. Orthologous to human PSMA2 (proteasome 20S subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12431321..12432556)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8257043..8258278)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Isolation and characterization of dominant suppressor of both Pros26' and Prosbeta2' that is a mutant allele of Pros25.
Title: A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

Names: 20s proteasome; CG5266-PA; Pros25; Prosalpha2-PA; Su(DTS)-1; alpha-subunit of 20S proteasome; alpha2; alpha2 subunit; proteasome 25kD subunit; proteasome subunit alpha-type 2; proteosome

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The following sections contain reference sequences that belong to a specific genome build. Explain