cav2 caveolin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cav2provided by ZNC
Official Full Name: caveolin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-164
See related: Ensembl:ENSDARG00000052000 AllianceGenome:ZFIN:ZDB-GENE-040625-164
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86696; wu:fc52e01
Summary: Predicted to enable molecular adaptor activity and protein kinase binding activity. Predicted to be involved in several processes, including caveola assembly; insulin receptor signaling pathway; and negative regulation of endothelial cell proliferation. Predicted to be located in Golgi membrane and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to colocalize with caveola; focal adhesion; and sarcolemma. Human ortholog(s) of this gene implicated in low tension glaucoma and primary open angle glaucoma. Orthologous to human CAV2 (caveolin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (18556606..18561795)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (18460206..18465395)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in caveola assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within caveola assembly	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with caveola	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with sarcolemma	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: caveolin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.