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gtf2f2a general transcription factor IIF, polypeptide 2a [ Danio rerio (zebrafish) ]

Gene ID: 415217, updated on 11-Apr-2024

Summary

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Official Symbol
gtf2f2aprovided by ZNC
Official Full Name
general transcription factor IIF, polypeptide 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-131
See related
Ensembl:ENSDARG00000069910 AllianceGenome:ZFIN:ZDB-GENE-040625-131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gtf2f2; zgc:86775; wu:fb39a05
Summary
Predicted to enable several functions, including ATP binding activity; DNA binding activity; and DNA helicase activity. Predicted to be involved in transcription initiation from RNA polymerase II promoter. Predicted to act upstream of or within transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIF complex. Orthologous to human GTF2F2 (general transcription factor IIF subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (34695341..34706903)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (33962773..33974335)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene GPALPP motifs containing 1 Neighboring gene tumor protein, translationally-controlled 1 Neighboring gene uncharacterized LOC110439843

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC174761

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIF complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
general transcription factor IIF subunit 2
Names
general transcription factor IIF, polypeptide 2, 30kDa
NP_001002127.2
NP_001096603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002127.2 → NP_001002127.2  general transcription factor IIF subunit 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CF999714, EH546307, EH556805, EH577899
    UniProtKB/TrEMBL
    A0A8M1MZY4, B8JHR3
    Related
    ENSDARP00000092894.3, ENSDART00000102118.5
    Conserved Domains (1) summary
    pfam02270
    Location:13 → 252
    TFIIF_beta; Transcription initiation factor IIF, beta subunit

  2. NM_001103133.2 → NP_001096603.1  general transcription factor IIF subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001096603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    EH434904, EH546307, EH556805, EH577899
    UniProtKB/TrEMBL
    A0A8M1NFS0, A7MCQ3
    Related
    ENSDARP00000072210.3, ENSDART00000077744.5
    Conserved Domains (1) summary
    pfam02270
    Location:13 → 236
    TFIIF_beta; Transcription initiation factor IIF, beta subunit

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    34695341..34706903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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