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mapk11 mitogen-activated protein kinase 11 [ Danio rerio (zebrafish) ]

Gene ID: 415185, updated on 27-Mar-2024

Summary

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Official Symbol
mapk11provided by ZNC
Official Full Name
mitogen-activated protein kinase 11provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-75
See related
Ensembl:ENSDARG00000045836 AllianceGenome:ZFIN:ZDB-GENE-040625-75
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86905
Summary
Predicted to enable MAP kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in granule cell. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (5506959..5522440)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (5498389..5513870)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene soluble scavenger receptor cysteine-rich domain-containing protein SSC5D-like Neighboring gene deleted in malignant brain tumors 1 protein-like Neighboring gene mitogen-activated protein kinase 12b Neighboring gene si:dkey-14d8.6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Reduction in Toxicity of Nano-Ag-Polyvinyl-pyrrolidone Using Hydra Proteins and Peptides during Zebrafish Embryogenesis. Kim SS, et al. Nanomaterials (Basel), 2019 Aug 27. PMID 31462001, Free PMC Article
  2. Transcriptomic analysis reveals potential mechanisms of toxicity in a combined exposure to dibutyl phthalate and diisobutyl phthalate in zebrafish (Danio rerio) ovary. Chen H, et al. Aquat Toxicol, 2019 Nov. PMID 31518775
  3. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194
  4. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 11
NP_001002095.1
XP_017210482.1
XP_021330662.1
XP_021330663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002095.1 → NP_001002095.1  mitogen-activated protein kinase 11

    See identical proteins and their annotated locations for NP_001002095.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071526
    UniProtKB/TrEMBL
    A0A8M1MZX2, Q6IQ84
    Related
    ENSDARP00000034350.5, ENSDART00000032857.7
    Conserved Domains (2) summary
    cd07878
    Location:7 → 349
    STKc_p38beta; Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11)
    smart00220
    Location:23 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    5506959..5522440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474987.1 → XP_021330662.1  mitogen-activated protein kinase 11 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PH56
    Conserved Domains (1) summary
    cl21453
    Location:21 → 268
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017354993.2 → XP_017210482.1  mitogen-activated protein kinase 11 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5A8

  3. XM_021474988.1 → XP_021330663.1  mitogen-activated protein kinase 11 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PUC2
    Conserved Domains (1) summary
    cl21453
    Location:1 → 242
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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