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rac2 Rac family small GTPase 2 [ Danio rerio (zebrafish) ]

Gene ID: 415151, updated on 11-Apr-2024

Summary

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Official Symbol
rac2provided by ZNC
Official Full Name
Rac family small GTPase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-27
See related
Ensembl:ENSDARG00000038010 AllianceGenome:ZFIN:ZDB-GENE-040625-27
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86686
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within several processes, including defense response to other organism; leukocyte chemotaxis; and regulation of neutrophil migration. Located in cytoplasm. Is expressed in blood island; caudal hematopoietic tissue; neutrophil; rostral blood island; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (29510843..29543269)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (29380001..29412427)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83 member Fa Neighboring gene cytohesin 4a Neighboring gene somatostatin receptor 3 Neighboring gene eukaryotic translation initiation factor 3, subunit D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata. Horton MV, et al. mSphere, 2021 Jun 30. PMID 34160238, Free PMC Article
  2. Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. Bastos RW, et al. mSphere, 2020 Apr 8. PMID 32269156, Free PMC Article
  3. Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains. Blachowicz A, et al. mBio, 2020 Feb 18. PMID 32071276, Free PMC Article
  4. Control of Mucosal Candidiasis in the Zebrafish Swim Bladder Depends on Neutrophils That Block Filament Invasion and Drive Extracellular-Trap Production. Gratacap RL, et al. Infect Immun, 2017 Sep. PMID 28607100, Free PMC Article
  5. Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station. Knox BP, et al. mSphere, 2016 Sep-Oct. PMID 27830189, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. iR-722 downregulates the transcript level of rac2 through binding to seed-matching sequence in the rac2 3'UTR.
    Title: Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.
  2. this study shows that in rac2-/- larvae both neutrophils and macrophages are defective in basic motility, leading to impaired responses to localized wounds or infections
    Title: Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.
  3. Rac inhibition decreased neutrophil respiratory burst, NET release, and phagocytosis.
    Title: Rac2 expression and its role in neutrophil functions of zebrafish (Danio rerio).
  4. Loss of rac2 is associated with immune deficiency.
    Title: Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within macrophage migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil mediated immunity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of neutrophil extravasation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pro-T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related C3 botulinum toxin substrate 2
Names
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002061.1 → NP_001002061.1  ras-related C3 botulinum toxin substrate 2

    See identical proteins and their annotated locations for NP_001002061.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071369
    UniProtKB/TrEMBL
    A0A8M1MZW3, Q6IQN5
    Related
    ENSDARP00000055406.3, ENSDART00000055407.5
    Conserved Domains (2) summary
    smart00174
    Location:6 → 179
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01871
    Location:3 → 176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    29510843..29543269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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