CYP2C18 cytochrome P450 2C21 [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: CYP2C18
Gene description: cytochrome P450 2C21
See related: Ensembl:ENSCAFG00845022726
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: CYP2C19; CYP2C21; CYPIIC21
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Genomic context

Location:: chromosome: 28

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	28	NC_051832.1 (8990157..9013592, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	28	NC_006610.4 (8903247..8926662, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	28	NC_049249.1 (8908600..8932042, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	28	NC_049288.1 (8706115..8729532, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	28	NC_049769.1 (8764810..8788314, complement)

Chromosome 28 - NC_051832.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report a non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
Title: A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
In acute coronary syndromes who have percutaneous intervention, when both ABCB1 and CYP2C19 are taken into account this genotype associated with increased risk of major adverse cardiovascular events while on standard doses of clopidogrel.
Title: Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in organic acid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cytochrome P450 2C21

Names: Cytochrome-P450-2C21; cytochrome P450 DM1-1

NP_001183973.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.