puraa purine-rich element binding protein Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: puraaprovided by ZNC
Official Full Name: purine-rich element binding protein Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040624-8
See related: Ensembl:ENSDARG00000067591 AllianceGenome:ZFIN:ZDB-GENE-040624-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pura; zgc:103411
Summary: Enables double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation; negative regulation of transcription, DNA-templated; and regulation of cell population proliferation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 31. Orthologous to human PURA (purine rich element binding protein A). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (28728232..28729250)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (28691537..28692555)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

repressor of gata2 gene expression in the nervous system
Title: Pur alpha and Sp8 as opposing regulators of neural gata2 expression.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables purine-rich negative regulatory element binding	IBA Inferred from Biological aspect of Ancestor more info
enables purine-rich negative regulatory element binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: purine-rich element binding protein Aa

Names: pur-alpha; purine-rich element binding protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001846.2 → NP_001001846.1 purine-rich element binding protein Aa

See identical proteins and their annotated locations for NP_001001846.1

Status: VALIDATED

Source sequence(s)

CT573432

UniProtKB/TrEMBL

A7MBQ8, Q6JIZ2

Related

ENSDARP00000101909.1, ENSDART00000097307.4

Conserved Domains (2) summary

smart00712
Location:41 → 103

PUR; DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria

pfam04845
Location:39 → 256

PurA; PurA ssDNA and RNA-binding protein