CYP7A1 cytochrome P450 family 7 subfamily A member 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CYP7A1provided by CGNC
Full Name: cytochrome P450 family 7 subfamily A member 1provided by CGNC
Primary source: CGNC:11501
See related: Ensembl:ENSGALG00010003518
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (111729524..111737083, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (111736000..111743552, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Title: Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Dietary CLA supplementation decreased the accumulation of lipids including abdominal fat and cholesterol in the liver and egg of laying hens, probably by upregulating hepatic LDLR expression and downregulating hepatic HMGR and CYP7A1 expression.
Title: Conjugated linoleic acid regulates lipid metabolism through the expression of selected hepatic genes in laying hens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cholesterol 7-alpha-monooxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cholesterol catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cholesterol 7-alpha-monooxygenase

Names: cholesterol 7 alpha-hydroxylase; cholesterol 7alpha-hydroxylase; cytochrome P450 7A1; cytochrome P450, family 7, subfamily A, polypeptide 1

NP_001001753.2

EC 1.14.14.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001753.2 → NP_001001753.2 cholesterol 7-alpha-monooxygenase

Status: PROVISIONAL

Source sequence(s)

JAENSK010000043

UniProtKB/TrEMBL

A0A8V0X9V3, Q76CE9

Related

ENSGALP00010004889.1, ENSGALT00010008223.1

Conserved Domains (1) summary

cl12078
Location:33 → 470

p450; Cytochrome P450

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

111729524..111737083 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

111736000..111743552 complement

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GenBank, FASTA, Sequence Viewer (Graphics)