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lck LCK proto-oncogene, Src family tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 414333, updated on 11-Apr-2024

Summary

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Official Symbol
lckprovided by ZNC
Official Full Name
LCK proto-oncogene, Src family tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040617-1
See related
Ensembl:ENSDARG00000102525 AllianceGenome:ZFIN:ZDB-GENE-040617-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:136695
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in T cell differentiation; cell surface receptor signaling pathway; and innate immune response. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in T cell; head kidney; lymphocyte; pro-T cell; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human LCK (LCK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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Location:
chromosome: 17
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (25344736..25382420, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (25326345..25364029, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 4 (inducible form) Neighboring gene transmembrane protein 54a Neighboring gene zona pellucida protein C Neighboring gene uncharacterized LOC110438042 Neighboring gene family with sequence similarity 167 member B Neighboring gene zgc:154055

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus. Rutherford HA, et al. Dis Model Mech, 2022 Apr 1. PMID 35142349, Free PMC Article
  2. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Langenau DM, et al. Proc Natl Acad Sci U S A, 2004 May 11. PMID 15123839, Free PMC Article
  3. T lymphocyte-dependent and -independent regulation of Cxcl8 expression in zebrafish intestines. Brugman S, et al. J Immunol, 2014 Jan 1. PMID 24277695
  4. Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency. Sertori R, et al. Front Immunol, 2022. PMID 35967429, Free PMC Article
  5. The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia. Zhou Y, et al. Haematologica, 2021 May 1. PMID 32817283, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC136695, MGC194004, MGC194043

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hemopoiesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Lck
Names
lymphocyte protein tyrosine kinase
lymphocyte-specific protein tyrosine kinase
NP_001001596.1
NP_001035418.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001596.1 → NP_001001596.1  tyrosine-protein kinase Lck isoform 1

    See identical proteins and their annotated locations for NP_001001596.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the isoform (1).
    Source sequence(s)
    AY390224
    UniProtKB/TrEMBL
    Q6TPQ4
    Related
    ENSDARP00000131919.1, ENSDART00000162306.2
    Conserved Domains (4) summary
    cd10362
    Location:116 → 216
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:57 → 111
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:230 → 493
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:238 → 487
    Pkinase_Tyr; Protein tyrosine kinase

  2. NM_001040328.1 → NP_001035418.1  tyrosine-protein kinase Lck isoform 2

    See identical proteins and their annotated locations for NP_001035418.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is the same length but differs from isoform 1.
    Source sequence(s)
    BC115230
    UniProtKB/TrEMBL
    B3DGD3, Q1RLY5
    Related
    ENSDARP00000130859.1, ENSDART00000165282.2
    Conserved Domains (4) summary
    cd10362
    Location:116 → 216
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:57 → 111
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:230 → 493
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:238 → 487
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    25344736..25382420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394991.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    271515..309199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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