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Taf12 TBP-associated factor 12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41406, updated on 4-Apr-2024

Summary

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Official Symbol
Taf12provided by FlyBase
Official Full Name
TBP-associated factor 12provided by FlyBase
Primary source
FLYBASE:FBgn0011290
Locus tag
Dmel_CG17358
See related
AllianceGenome:FB:FBgn0011290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17358; d28/22; Dmel\CG17358; dmTAF12; dTaf12; dTAF12; dTAF22; dTAF28; dTAFII30; dTAFII30 alpha; dTAF[[II]]30; dTAF[[II]]30alpha; dTAF[[II]]30alpha/22; p22; p28; T2DA_DROME; TAF; taf12; TAF12; Taf22; Taf28; TAF30a; Taf30alpha; TAF30alpha; TAF30alpha/28; TAF30alpha/28/22; Taf32; TAFII30alpha/22; TAF[II]30alpha; TAF[[II]]; TAF[[II]]230; Taf[[II]]30alpha; TAF[[II]]30alpha; TAF[[II]]30alpha/28 TAF[[II]]22; TAF[[II]]30alpha/28/22; TFIID; TFIID 22; TFIID 28; TFIID-p28
Summary
Enables protein homodimerization activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in histone H3 acetylation. Located in nucleus. Part of SAGA complex and transcription factor TFIID complex. Is expressed in organism. Orthologous to human TAF12 (TATA-box binding protein associated factor 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Taf12 in Genome Data Viewer
Location:
86E15-86E15; 3-51 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11678386..11679690, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7504108..7505412, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heme oxygenase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of RNA polymerase II transcription. Berk AJ. Curr Opin Cell Biol, 1999 Jun. PMID 10395559
  2. X-ray crystallographic studies of eukaryotic transcription factors. Burley SK. Cold Spring Harb Symp Quant Biol, 1998. PMID 10384268
  3. The role of TAFs in RNA polymerase II transcription. Hahn S. Cell, 1998 Nov 25. PMID 9845358
  4. UV cross-linking identifies four polypeptides that require the TATA box to bind to the Drosophila hsp70 promoter. Gilmour DS, et al. Mol Cell Biol, 1990 Aug. PMID 2370864, Free PMC Article
  5. c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro. Lively TN, et al. J Biol Chem, 2001 Jul 6. PMID 11316804

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IEA
Inferred from Electronic Annotation
more info
  
part_of SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
TBP-associated factor 12
Names
26kDa polypeptide
CG17358-PA
CG17358-PB
CG17358-PD
CG17358-PE
TBP-associated factor
TBP-associated factor 30kD subunit alpha
Taf12-PA
Taf12-PB
Taf12-PD
Taf12-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11678386..11679690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169421.3 → NP_731617.2  TBP-associated factor 12, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731617.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFN0
    Conserved Domains (1) summary
    cd07981
    Location:55 → 126
    TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  2. NM_001275550.1 → NP_001262479.1  TBP-associated factor 12, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262479.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFN0
    Conserved Domains (1) summary
    cd07981
    Location:55 → 126
    TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  3. NM_169420.2 → NP_731616.1  TBP-associated factor 12, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731616.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2Q1, P49905, Q26339, Q9VGK0
    Related
    FBpp0081916
    Conserved Domains (1) summary
    pfam03847
    Location:93 → 159
    TFIID_20kDa; Transcription initiation factor TFIID subunit A

  4. NM_079596.3 → NP_524320.1  TBP-associated factor 12, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524320.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2Q1, P49905, Q26339, Q9VGK0
    Related
    FBpp0081918
    Conserved Domains (1) summary
    pfam03847
    Location:93 → 159
    TFIID_20kDa; Transcription initiation factor TFIID subunit A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFN0 A0A0B4KFN0
P49905.1 P49905

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