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rump rumpelstiltskin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41138, updated on 10-May-2024

Summary

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Official Symbol
rumpprovided by FlyBase
Official Full Name
rumpelstiltskinprovided by FlyBase
Primary source
FLYBASE:FBgn0267790
Locus tag
Dmel_CG9373
See related
AllianceGenome:FB:FBgn0267790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg9373; CG9373; Dmel\CG9373; hnRNP M; HnRNP-S5; hrp59; Hrp59; p70; p75; Rump; S5
Summary
Enables mRNA 3'-UTR binding activity. Involved in pole cell development and pole plasm oskar mRNA localization. Located in chromatin; cytoplasm; and omega speckle. Part of ribonucleoprotein complex. Is expressed in several structures, including embryonic/larval nervous system; endoderm anlage; extended germ band embryo; germ layer; and presumptive embryonic/larval system. Orthologous to human HNRNPM (heterogeneous nuclear ribonucleoprotein M) and MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
85D18-85D19; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9505853..9510324, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5331575..5336046, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene phurba tashi Neighboring gene Rho-like Neighboring gene uncharacterized protein Neighboring gene Ras oncogene at 85D Neighboring gene Rlb1 Neighboring gene mitochondrial ribosomal protein L47

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Monoclonal antibodies against chromosomal proteins of Drosophila melanogaster: establishment of antibody producing cell lines and partial characterization of corresponding antigens. Saumweber H, et al. Chromosoma, 1980. PMID 6777121
  2. Recognition and long-range interactions of a minimal nanos RNA localization signal element. Bergsten SE, et al. Development, 2001 Feb. PMID 11152641
  3. Co-transcriptional architecture in a Y loop in Drosophila melanogaster. Redhouse JL, et al. Chromosoma, 2011 Aug. PMID 21556802
  4. The Drosophila heterogeneous nuclear ribonucleoprotein M protein, HRP59, regulates alternative splicing and controls the production of its own mRNA. Hase ME, et al. J Biol Chem, 2006 Dec 22. PMID 17077090
  5. The RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner. King MR, et al. J Cell Sci, 2014 Jul 1. PMID 24706949, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. suggesting that Rump and Lost are part of a core localization complex that promotes utilization of the late localization pathway by multiple mRNAs in parallel
    Title: A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin.
  2. Data show that depletion of Hrp59 by RNA interference reduces the levels of Rrp4 at transcription sites, which suggests that Hrp59 is needed for the exosome to stably interact with nascent pre-mRNPs.
    Title: The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteins.
  3. Rumpelstiltskin (rump) regulates anterior-posterior axis patterning by functioning as a direct-acting nanos mRNA localization factor.
    Title: The Drosophila hnRNP M homolog Rumpelstiltskin regulates nanos mRNA localization.
  4. the ability of HRP59 to regulate the alternative splicing of its own pre-mRNA serves in a negative feedback loop that controls the levels of the HRP59 protein and maintains the homeostasis of the splicing environment.
    Title: The Drosophila heterogeneous nuclear ribonucleoprotein M protein, HRP59, regulates alternative splicing and controls the production of its own mRNA.
  5. Hrp59 is required for the expression of target mRNAs. Hrp59 binds preferentially to exonic splicing enhancers and our results provide new insights into the role of hnRNP M in splicing regulation.
    Title: Hrp59, an hnRNP M protein in Chironomus and Drosophila, binds to exonic splicing enhancers and is required for expression of a subset of mRNAs.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, embryo IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle HMP PubMed 
involved_in pole cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pole plasm oskar mRNA localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in segmentation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in omega speckle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rumpelstiltskin
Names
CG9373-PA
CG9373-PB
Hrp59
heterogeneous nuclear ribonucleoprotein M
heterogeneous nuclear ribonucleoprotein S5
p75
rump-PA
rump-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9505853..9510324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260075.2 → NP_001247004.1  rumpelstiltskin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247004.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6Z1
    Conserved Domains (2) summary
    COG0724
    Location:50 → 131
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12385
    Location:58 → 133
    RRM1_hnRNPM_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins

  2. NM_141642.3 → NP_649899.1  rumpelstiltskin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649899.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHC7
    Related
    FBpp0081601
    Conserved Domains (5) summary
    TIGR01628
    Location:48 → 435
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    COG0724
    Location:543 → 631
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12385
    Location:58 → 133
    RRM1_hnRNPM_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12386
    Location:234 → 307
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cl17169
    Location:565 → 630
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6Z1 A0A0B4K6Z1
Q8MSI9 Q8MSI9
Q9VHC7 Q9VHC7

Gene LinkOut

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