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RPA1 Replication protein A1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40972, updated on 4-Apr-2024

Summary

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Official Symbol
RPA1provided by FlyBase
Official Full Name
Replication protein A1provided by FlyBase
Primary source
FLYBASE:FBgn0010173
Locus tag
Dmel_CG9633
See related
AllianceGenome:FB:FBgn0010173
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9633; D-RPA70; D-SSB; Dmel\CG9633; DmRPA; dmrpa1; dRP-A; DRP-A; i164; RP-A; RPA; RPA 70; RPA 70 kDa; Rpa-70; RpA-70; RpA1; RpA70; RPA70; Ssb-70
Summary
Enables single-stranded DNA binding activity. Involved in DNA-dependent DNA replication. Located in nucleus. Part of DNA replication factor A complex. Is expressed in several structures, including embryonic brain; extended germ band embryo; germ layer; gonad; and gut section. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
84F6-84F6; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8262120..8264451, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4087842..4090173, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mind the gap Neighboring gene pseudo Neighboring gene Minichromosome maintenance 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A second hybrid-binding domain modulates the activity of Drosophila ribonuclease H1. González de Cózar JM, et al. J Biochem, 2020 Nov 1. PMID 32589740, Free PMC Article
  2. Asymmetric histone inheritance via strand-specific incorporation and biased replication fork movement. Wooten M, et al. Nat Struct Mol Biol, 2019 Aug. PMID 31358945, Free PMC Article
  3. Phosphorylation and localization of replication protein A during oogenesis and early embryogenesis of Drosophila melanogaster. Mitsis PG. Dev Biol, 1995 Aug. PMID 7649375
  4. Purification and characterisation of a DNA helicase, dheI I, from Drosophila melanogaster embryos. Thömmes P, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501468, Free PMC Article
  5. A new DNA polymerase species from Drosophila melanogaster: a probable mus308 gene product. Oshige M, et al. Mutat Res, 1999 Apr 9. PMID 10343651

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. loss-of-function alleles indicate that RPA is required to prevent neuroepithelial cells from differentiating into medulla neuroblasts
    Title: Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development.
  2. Data show that the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling.
    Title: The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor A complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
replication protein A1
Names
CG9633-PA
RPA1-PA
drosophila replication protein A
replication protein A 70
single stranded-binding protein 70

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8262120..8264451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079550.4 → NP_524274.1  replication protein A1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24492, Q9VHU3
    Related
    FBpp0081356
    Conserved Domains (5) summary
    cd04474
    Location:168 → 270
    RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    cd04475
    Location:301 → 401
    RPA1_DBD_B; RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    TIGR00617
    Location:3 → 595
    rpa1; replication factor-a protein 1 (rpa1)
    pfam04057
    Location:6 → 107
    Rep-A_N; Replication factor-A protein 1, N-terminal domain
    pfam08646
    Location:444 → 589
    Rep_fac-A_C; Replication factor-A C terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24492.1 Q24492

Gene LinkOut

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