Capn11 calpain 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Capn11provided by RGD
Full Name: calpain 11provided by RGD
Primary source: RGD:1302946
See related: Ensembl:ENSRNOG00000026025 AllianceGenome:RGD:1302946
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in acrosomal vesicle. Predicted to be active in cytoplasm. Orthologous to human CAPN11 (calpain 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 86.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (22841500..22863042)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (15344059..15365604)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (17728845..17750357)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calpain 11

Names: CANP 11; calcium-activated neutral proteinase 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002806.2 → NP_001002806.2 calpain 11

See identical proteins and their annotated locations for NP_001002806.2

Status: VALIDATED

Source sequence(s)

BC097256

UniProtKB/Swiss-Prot

Q4V8Q1, Q6IE72

UniProtKB/TrEMBL

D3ZXF4

Related

ENSRNOP00000059934.3, ENSRNOT00000065754.5

Conserved Domains (3) summary

cd00051
Location:591 → 641

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00648
Location:56 → 352

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:367 → 520

Calpain_III; Calpain large subunit, domain III

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

22841500..22863042

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084029.2 → XP_038939957.1 calpain 11 isoform X1

UniProtKB/Swiss-Prot

Q4V8Q1, Q6IE72

Related

ENSRNOP00000083385.1

Conserved Domains (4) summary

cd00214
Location:367 → 521

Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

cd15897
Location:543 → 571

EFh_PEF; EF-hand motif [structural motif]

cl25352
Location:543 → 711

EFh_PEF; The penta-EF hand (PEF) family

pfam00648
Location:56 → 352

Peptidase_C2; Calpain family cysteine protease
XM_063267562.1 → XP_063123632.1 calpain 11 isoform X3
XM_063267563.1 → XP_063123633.1 calpain 11 isoform X4
XM_063267561.1 → XP_063123631.1 calpain 11 isoform X2
XM_063267564.1 → XP_063123634.1 calpain 11 isoform X5