TMSB4X thymosin beta 4X [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: TMSB4Xprovided by CGNC
Official Full Name: thymosin beta 4Xprovided by CGNC
Primary source: CGNC:49900
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: TB4; TMSB4A; thymosin-beta
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (123512192..123514181, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (123473654..123475649, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMSB4X expression was detected higher in the chicken epididymis than that of brain, kidney, liver, muscle, ovary, and testis.
Title: Comparative expression and regulation of TMSB4X in male reproductive tissues of rats and chickens.
Tbeta4 expression has a large impact on neuroepithelial and macroscopic brain development
Title: Thymosin β4 induces folding of the developing optic tectum in the chicken (Gallus domesticus).
thymosin-beta and its derivative peptides have roles in the programmed cell death of chick and rat neurons
Title: Neuroprotective function of thymosin-beta and its derivative peptides on the programmed cell death of chick and rat neurons.
High similarity to expression in mice, mainly in heart and nervous system. Important new aspects are early onset of expression, expression in mesoderm preceding heart formation, and involvement in feather development.
Title: Expression of thymosin beta4 during chick development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin monomer binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sequestering of actin monomers	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: thymosin beta-4

Names: thymosin beta 4, X-linked; thymosin beta 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001315.3 → NP_001001315.2 thymosin beta-4

Status: VALIDATED

Source sequence(s)

JAENSK010000024

UniProtKB/TrEMBL

Q6WEB3

Conserved Domains (1) summary

pfam01290
Location:3 → 41

Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

123512192..123514181 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046926308.1 → XP_046782264.1 thymosin beta-4 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

123473654..123475649 complement

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GenBank, FASTA, Sequence Viewer (Graphics)