U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CACNA1C calcium voltage-gated channel subunit alpha1 C [ Bos taurus (cattle) ]

Gene ID: 408015, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
CACNA1Cprovided by VGNC
Official Full Name
calcium voltage-gated channel subunit alpha1 Cprovided by VGNC
Primary source
VGNC:VGNC:59325
See related
Ensembl:ENSBTAG00000010660
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CAV1.2
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 5
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (108334919..108794045)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene protein SDA1 homolog Neighboring gene adiponectin receptor 2 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene leucine rich repeats and transmembrane domains 2 Neighboring gene decapping mRNA 1B Neighboring gene uncharacterized LOC101903199 Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene putative uncharacterized protein FLJ46204 Neighboring gene uncharacterized LOC104970340 Neighboring gene uncharacterized LOC132345351 Neighboring gene transmembrane protein 121B Neighboring gene interleukin 17 receptor A

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx. Marom M, et al. J Biol Chem, 2010 Mar 5. PMID 20054004, Free PMC Article
  2. Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture. Walsh CP, et al. J Biol Chem, 2009 Aug 14. PMID 19520861, Free PMC Article
  3. Adrenal medulla calcium channel population is not conserved in bovine chromaffin cells in culture. Benavides A, et al. Neuroscience, 2004. PMID 15450357
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that structural rearrangements of CaV1.2 generated through the binding of BayK8644 or FPL64176, by altering the channel activity, could affect depolarization-evoked catecholamine secretion prior to cation transport.
    Title: Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx.
  2. CaV3.1 structural analysis and comparison to CaV1.2 channel
    Title: Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
voltage-dependent L-type calcium channel subunit alpha-1C
Names
calcium channel, voltage-dependent, L type, alpha 1C subunit
voltage-gated calcium channel alpha 1C subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    108334919..108794045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024992752.2 → XP_024848520.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X6

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1516
    Ion_trans; Ion transport protein
    pfam08763
    Location:1589 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1683 → 2130
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1517 → 1587
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_024992747.2 → XP_024848515.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X2

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1516
    Ion_trans; Ion transport protein
    pfam08763
    Location:1589 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1683 → 2130
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1517 → 1587
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_024992758.2 → XP_024848526.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X11

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1505
    Ion_trans; Ion transport protein
    pfam08763
    Location:1578 → 1649
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1672 → 2119
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1506 → 1576
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_024992753.2 → XP_024848521.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X7

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1516
    Ion_trans; Ion transport protein
    pfam08763
    Location:1589 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1683 → 2130
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1517 → 1587
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_024992750.2 → XP_024848518.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X5

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1516
    Ion_trans; Ion transport protein
    pfam08763
    Location:1589 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1683 → 2130
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1517 → 1587
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_024992755.2 → XP_024848523.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X8

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1514
    Ion_trans; Ion transport protein
    pfam08763
    Location:1587 → 1658
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1681 → 2128
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1515 → 1585
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. XM_024992764.2 → XP_024848532.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X15

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:152 → 445
    Ion_trans; Ion transport protein
    pfam08763
    Location:1637 → 1708
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1731 → 2178
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1565 → 1635
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. XM_024992749.2 → XP_024848517.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X4

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1516
    Ion_trans; Ion transport protein
    pfam08763
    Location:1589 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1683 → 2130
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1517 → 1587
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. XM_024992746.2 → XP_024848514.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:152 → 445
    Ion_trans; Ion transport protein
    pfam08763
    Location:1589 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1683 → 2130
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1517 → 1587
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  10. XM_024992757.2 → XP_024848525.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X12

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1505
    Ion_trans; Ion transport protein
    pfam08763
    Location:1578 → 1649
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1672 → 2119
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1506 → 1576
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  11. XM_024992761.2 → XP_024848529.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X13

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1503
    Ion_trans; Ion transport protein
    pfam08763
    Location:1576 → 1647
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1670 → 2117
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1504 → 1574
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  12. XM_024992748.2 → XP_024848516.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X3

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:152 → 445
    Ion_trans; Ion transport protein
    pfam08763
    Location:1589 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1683 → 2130
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1517 → 1587
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  13. XM_024992760.2 → XP_024848528.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X10

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:1247 → 1505
    Ion_trans; Ion transport protein
    pfam08763
    Location:1578 → 1649
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1672 → 2119
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1506 → 1576
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  14. XM_024992756.2 → XP_024848524.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X9

    UniProtKB/TrEMBL
    F1N5T3
    Conserved Domains (4) summary
    pfam00520
    Location:152 → 441
    Ion_trans; Ion transport protein
    pfam08763
    Location:1585 → 1656
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1679 → 2126
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1513 → 1583
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  15. XM_024992763.2 → XP_024848531.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X14

    UniProtKB/TrEMBL
    F1N5T3
    Related
    ENSBTAP00000014104.7, ENSBTAT00000014104.7
    Conserved Domains (4) summary
    pfam00520
    Location:123 → 416
    Ion_trans; Ion transport protein
    pfam08763
    Location:1560 → 1631
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1654 → 2101
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1488 → 1558
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.