U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CRAT Carnitine O-Acetyl-Transferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40787, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
CRATprovided by FlyBase
Official Full Name
Carnitine O-Acetyl-Transferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037440
Locus tag
Dmel_CG1041
See related
AllianceGenome:FB:FBgn0037440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1041; CrAT; Dmel\CG1041
Summary
Predicted to enable carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked. Located in peroxisome. Is expressed in adult brain cell body rind; adult gnathal ganglion; adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
83E4-83E5; 3-47.5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6371026..6376044, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2196748..2201662, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene p21-activated kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transcription factor IIFalpha

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster. Faust JE, et al. PLoS One, 2014. PMID 24945818, Free PMC Article
  2. L-Carnitine in Drosophila: A Review. Carillo MR, et al. Antioxidants (Basel), 2020 Dec 21. PMID 33371457, Free PMC Article
  3. Phosphatidic acid as a limiting host metabolite for the proliferation of the microsporidium Tubulinosema ratisbonensis in Drosophila flies. Franchet A, et al. Nat Microbiol, 2019 Apr. PMID 30692666
  4. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. Steele LD, et al. PLoS One, 2015. PMID 25826265, Free PMC Article
  5. Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Şentürk M, et al. Nat Cell Biol, 2019 Mar. PMID 30804504, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in carnitine metabolic process, CoA-linked IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm HDA PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
carnitine O-Acetyl-Transferase
Names
CG1041-PA
CG1041-PB
CG1041-PD
CG1041-PE
CRAT-PA
CRAT-PB
CRAT-PD
CRAT-PE
carnitine O-acetyl-transferase
carnitine acetyltransferase
NP_001036684.1
NP_001287195.1
NP_001303419.1
NP_649650.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6371026..6376044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316490.1 → NP_001303419.1  carnitine O-Acetyl-Transferase, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUQ4
    Conserved Domains (1) summary
    pfam00755
    Location:50 → 624
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  2. NM_141393.2 → NP_649650.2  carnitine O-Acetyl-Transferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649650.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VI16
    Related
    FBpp0081231
    Conserved Domains (1) summary
    pfam00755
    Location:74 → 648
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  3. NM_001300266.1 → NP_001287195.1  carnitine O-Acetyl-Transferase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287195.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VI16
    Conserved Domains (1) summary
    pfam00755
    Location:74 → 648
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  4. NM_001043219.1 → NP_001036684.1  carnitine O-Acetyl-Transferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QP39, Q0KIA8
    Conserved Domains (1) summary
    pfam00755
    Location:69 → 643
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A126GUQ4 A0A126GUQ4
Q0KIA8 Q0KIA8
Q9VI16 Q9VI16

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous