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yes1 YES proto-oncogene 1, Src family tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 407620, updated on 11-Apr-2024

Summary

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Official Symbol
yes1provided by ZNC
Official Full Name
YES proto-oncogene 1, Src family tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050126-1
See related
Ensembl:ENSDARG00000005941 AllianceGenome:ZFIN:ZDB-GENE-050126-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
c-yes; p61-Yes
Summary
Enables protein tyrosine kinase activity. Acts upstream of or within several processes, including adherens junction maintenance; convergent extension involved in gastrulation; and protein autophosphorylation. Predicted to be located in cytosol; microtubule organizing center; and plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31308547..31363407)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31325329..31380189)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885430 Neighboring gene adenylate cyclase activating polypeptide 1b Neighboring gene clusterin-like 1 (retinal) Neighboring gene collectin sub-family member 12 Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo. Sempou E, et al. Mol Neurodegener, 2016 Feb 9. PMID 26860872, Free PMC Article
  2. Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. Lemeer S, et al. PLoS One, 2007 Jul 4. PMID 17611617, Free PMC Article
  3. Role of Yes kinase during early zebrafish development. Tsai WB, et al. Dev Biol, 2005 Jan 1. PMID 15572145
  4. Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. Yoo SK, et al. J Cell Biol, 2012 Oct 15. PMID 23045550, Free PMC Article
  5. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Huang H, et al. Development, 2007 Mar. PMID 17293535

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adherens junction maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase yes
Names
protein-tyrosine kinase
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
yes-kinase
NP_001013288.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013270.3 → NP_001013288.2  tyrosine-protein kinase yes

    See identical proteins and their annotated locations for NP_001013288.2

    Status: PROVISIONAL

    Source sequence(s)
    BC128657
    UniProtKB/Swiss-Prot
    A1A5H8, Q6EWH1, Q8AXW6
    Related
    ENSDARP00000009659.6, ENSDART00000027090.7
    Conserved Domains (3) summary
    cd09933
    Location:157 → 256
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:97 → 154
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:267 → 545
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    31308547..31363407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1A5H8.1 GenPept UniProtKB/Swiss-Prot:A1A5H8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.