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yes1 YES proto-oncogene 1, Src family tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 407620, updated on 4-Jan-2025

Summary

Official Symbol
yes1provided by ZNC
Official Full Name
YES proto-oncogene 1, Src family tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050126-1
See related
Ensembl:ENSDARG00000005941 AllianceGenome:ZFIN:ZDB-GENE-050126-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
c-yes; p61-Yes
Summary
Enables protein tyrosine kinase activity. Acts upstream of or within several processes, including adherens junction maintenance; convergent extension involved in gastrulation; and protein autophosphorylation. Predicted to be located in several cellular components, including anchoring junction; centrosome; and cytosol. Predicted to be active in plasma membrane. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See yes1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31308547..31363407)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31325329..31380189)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487898 Neighboring gene uncharacterized LOC101885430 Neighboring gene adenylate cyclase activating polypeptide 1b Neighboring gene clusterin-like 1 (retinal) Neighboring gene collectin sub-family member 12 Neighboring gene transmembrane protein 236 Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
enables kinase activity  
enables non-membrane spanning protein tyrosine kinase activity  
enables non-membrane spanning protein tyrosine kinase activity  
enables nucleotide binding  
enables protein kinase activity  
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity  
enables signaling receptor binding  
enables transferase activity  
Component Evidence Code Pubs
located_in anchoring junction  
located_in centrosome  
located_in cytoplasm  
located_in cytoskeleton  
located_in cytosol  
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
tyrosine-protein kinase yes
Names
protein-tyrosine kinase
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
yes-kinase
NP_001013288.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013270.3NP_001013288.2  tyrosine-protein kinase yes

    See identical proteins and their annotated locations for NP_001013288.2

    Status: PROVISIONAL

    Source sequence(s)
    BC128657
    UniProtKB/Swiss-Prot
    A1A5H8, Q6EWH1, Q8AXW6
    Related
    ENSDARP00000009659.6, ENSDART00000027090.7
    Conserved Domains (3) summary
    cd09933
    Location:157256
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:97154
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:267545
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    31308547..31363407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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