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creb3l3l cAMP responsive element binding protein 3-like 3 like [ Danio rerio (zebrafish) ]

Gene ID: 406853, updated on 27-Mar-2024

Summary

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Official Symbol
creb3l3lprovided by ZNC
Official Full Name
cAMP responsive element binding protein 3-like 3 likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2942
See related
Ensembl:ENSDARG00000020926 AllianceGenome:ZFIN:ZDB-GENE-040426-2942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
creb3l3; zgc:66452; wu:fj05f07
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in central nervous system; liver; notochord; sensory system; and yolk syncytial layer. Orthologous to human CREB3 (cAMP responsive element binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See creb3l3l in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (31375119..31384622, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (31365887..31375375, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene un-named hu7912 Neighboring gene growth arrest and DNA-damage-inducible, gamma a Neighboring gene NIM1 serine/threonine protein kinase a Neighboring gene zinc finger protein 131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Fasted zebrafish mimic genetic and physiological responses in mammals: a model for obesity and diabetes? Craig PM, et al. Zebrafish, 2011 Sep. PMID 21854210
  2. Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis. Turola E, et al. Dis Model Mech, 2015 Sep. PMID 26183212, Free PMC Article
  3. Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid. Zhang NS, et al. Environ Toxicol Pharmacol, 2014 Mar. PMID 24637248
  4. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Veldman MB, et al. Dev Biol, 2007 Dec 15. PMID 17949705
  5. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cAMP responsive element binding protein 3-like 3 like; cyclic AMP-responsive element-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213532.2 → NP_998697.2  cAMP responsive element binding protein 3-like 3 like

    See identical proteins and their annotated locations for NP_998697.2

    Status: VALIDATED

    Source sequence(s)
    AL929453, EH441942, EH467829
    UniProtKB/TrEMBL
    A0A8M2BEK7
    Related
    ENSDARP00000024846.8, ENSDART00000024872.9
    Conserved Domains (1) summary
    cd14689
    Location:228 → 288
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    31375119..31384622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167154.3 → XP_005167211.1  cyclic AMP-responsive element-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005167211.1

    UniProtKB/TrEMBL
    A0A8M2BEK7
    Conserved Domains (1) summary
    cd14689
    Location:228 → 288
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394733.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    131880..141311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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