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prpf4bb pre-mRNA processing factor 4Bb [ Danio rerio (zebrafish) ]

Gene ID: 406758, updated on 27-Mar-2024

Summary

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Official Symbol
prpf4bbprovided by ZNC
Official Full Name
pre-mRNA processing factor 4Bbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2799
See related
Ensembl:ENSDARG00000040310 AllianceGenome:ZFIN:ZDB-GENE-040426-2799
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prpf4b; zgc:55623; wu:fc18e10; wu:fe47g02
Summary
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within mRNA cis splicing, via spliceosome and phosphorylation. Predicted to be active in nucleus. Orthologous to human PRPF4B (pre-mRNA processing factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (11473568..11505969, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (11333201..11365602, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family, member 11 Neighboring gene atypical chemokine receptor 4b Neighboring gene PX domain containing 1b Neighboring gene GLI family zinc finger 3 Neighboring gene uncharacterized LOC101884290 Neighboring gene uncharacterized LOC103909741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Lemeer S, et al. J Proteome Res, 2008 Apr. PMID 18307296
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pre-mRNA processing factor 4Bb
Names
PRP4 pre-mRNA processing factor 4 homolog B
PRP4 pre-mRNA processing factor 4 homolog Bb
NP_998614.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213449.1 → NP_998614.1  pre-mRNA processing factor 4Bb

    See identical proteins and their annotated locations for NP_998614.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048879
    UniProtKB/TrEMBL
    Q7ZUL4
    Related
    ENSDARP00000097088.2, ENSDART00000106310.5
    Conserved Domains (2) summary
    smart00220
    Location:697 → 1006
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:689 → 1006
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    11473568..11505969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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