pdha1a pyruvate dehydrogenase E1 subunit alpha 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdha1aprovided by ZNC
Official Full Name: pyruvate dehydrogenase E1 subunit alpha 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2719
See related: Ensembl:ENSDARG00000012387 AllianceGenome:ZFIN:ZDB-GENE-040426-2719
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pdha1; zgc:73271; zgc:86692; im:6895726; wu:fd18b01; wu:fo96f03
Summary: Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including adaxial cell; alar plate midbrain region; heart tube; musculature system; and pronephric duct. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to several human genes including PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (24031313..24044724, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (23527516..23540924, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fk94c12.x1 (e-PCR)
- UniSTS:201759

fb02b04.y1 (e-PCR)
- UniSTS:189805

fk65a06.x1 (e-PCR)
- UniSTS:201357

fd18b01.x1 (e-PCR)
- UniSTS:204221

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 subunit alpha 1a

Names: pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase (lipoamide) alpha 1a; pyruvate dehydrogenase E1 alpha 1 subunit a

NP_998558.1

EC 1.2.4.1

XP_005165191.1

EC 1.2.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213393.1 → NP_998558.1 pyruvate dehydrogenase E1 subunit alpha 1a

See identical proteins and their annotated locations for NP_998558.1

Status: PROVISIONAL

Source sequence(s)

BC071373

UniProtKB/TrEMBL

Q6IQN1, Q6P948

Related

ENSDARP00000024338.5, ENSDART00000023784.7

Conserved Domains (1) summary

TIGR03182
Location:61 → 372

PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

24031313..24044724 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165134.4 → XP_005165191.1 pyruvate dehydrogenase E1 alpha 1 isoform X1

UniProtKB/TrEMBL

A0A0R4IT09, A0A8M2BCB9

Related

ENSDARP00000139481.1, ENSDART00000161131.2

Conserved Domains (1) summary

TIGR03182
Location:68 → 379

PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit