sfpq splicing factor proline/glutamine-rich [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sfpqprovided by ZNC
Official Full Name: splicing factor proline/glutamine-richprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2452
See related: Ensembl:ENSDARG00000011564 AllianceGenome:ZFIN:ZDB-GENE-040426-2452
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:85935; hm:zeh0027; wu:fa11h12; wu:fd10f03
Summary: Predicted to enable RNA binding activity. Acts upstream of or within central nervous system development and negative regulation of axon regeneration. Located in neuron projection and nucleus. Is expressed in brain; eye; gut; heart; and muscle cell. Orthologous to human SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (40026015..40055391)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (40438893..40468381)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons.
Title: A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons.
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
Title: Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq.
sfpq function is required for differentiation, but not for determination, of specific classes of brain neurons.
Title: Whitesnake/sfpq is required for cell survival and neuronal development in the zebrafish.

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General gene information

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Markers

fd10f03.x1 (e-PCR)
- UniSTS:204098

fa11h12.s1 (e-PCR)
- UniSTS:202330

aa494743 (e-PCR)
- UniSTS:186805

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within formation of anatomical boundary	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rhombomere boundary formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: splicing factor, proline- and glutamine-rich

Names: splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); wis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213278.1 → NP_998443.1 splicing factor, proline- and glutamine-rich

See identical proteins and their annotated locations for NP_998443.1

Status: PROVISIONAL

Source sequence(s)

BC068428

UniProtKB/TrEMBL

Q6NUU2

Related

ENSDARP00000020522.7, ENSDART00000017359.8

Conserved Domains (3) summary

cd12333
Location:295 → 374

RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family

cd12587
Location:219 → 289

RRM1_PSF; RNA recognition motif 1 in vertebrate polypyrimidine tract-binding protein (PTB)-associated-splicing factor (PSF)

cl06904
Location:365 → 461

eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family