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PEK pancreatic eIF-2alpha kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40653, updated on 11-Apr-2024

Summary

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Official Symbol
PEKprovided by FlyBase
Official Full Name
pancreatic eIF-2alpha kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037327
Locus tag
Dmel_CG2087
See related
AllianceGenome:FB:FBgn0037327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2087; Dmel\CG2087; DmPEK; dpERK; dPerk; dPERK; DpERK; DPERK; pek; Pek; PEK1; perk; pERK; Perk; PERK
Summary
Enables elongation factor-2 kinase activity. Involved in several processes, including PERK-mediated unfolded protein response; positive regulation of JNK cascade; and regulation of G2/M transition of mitotic cell cycle. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval muscle system; and visceral muscle primordium. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
83A4-83A4; 3-47.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5458563..5464753, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1284285..1290475, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Odorant receptor co-receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L35A Neighboring gene Polymerase (DNA-directed), delta interacting protein 2 Neighboring gene mitochondrial ribosomal protein L44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpressed PERK suppresses the neurodegenerative phenotypes in PINK1(B9) flies by enhancing mitochondrial function. Cui Y, et al. Neurochem Int, 2020 Nov. PMID 32898622
  2. Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK. Ly S, et al. Curr Biol, 2020 May 4. PMID 32169212, Free PMC Article
  3. PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila. Elvira R, et al. Int J Mol Sci, 2020 Jan 28. PMID 32013014, Free PMC Article
  4. p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress. Thomas SE, et al. J Biol Chem, 2013 Mar 15. PMID 23341460, Free PMC Article
  5. Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease. Popovic R, et al. Cell Death Dis, 2023 Mar 22. PMID 36949073, Free PMC Article

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy.
    Title: PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy.
  2. Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease.
    Title: Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease.
  3. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha.
    Title: Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α.
  4. The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila.
    Title: The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila.
  5. Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.
    Title: Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.
  6. Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
    Title: Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
  7. PERK-Mediated eIF2alpha Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.
    Title: PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.
  8. X-box binding protein 1 overexpression at an early stage reversed Abeta-induced early death without affecting learning performance in the Abeta42 transgenic flies. PERK activation was determined to only enhance Abeta-induced learning deficits.
    Title: XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology.
  9. PERK and GCN2 act on FOXO to potentiate FOXO activity which has been implicated in the development and progression of a variety of diseases.
    Title: eIF2α kinases PERK and GCN2 act on FOXO to potentiate FOXO activity.
  10. We show that the PKR-like ER kinase (PERK) integrates both cell-autonomous and non-autonomous endoplasmic reticulum stress stimuli to induce intestinal stem cell proliferation.
    Title: PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in PERK-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in PERK-mediated unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in PERK-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eiF2alpha phosphorylation in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pancreatic eIF-2alpha kinase
Names
CG2087-PA
CG2087-PB
CG2087-PC
PEK-PA
PEK-PB
PEK-PC
PERK
pancreatic eIF2alpha kinase
protein kinase RNA-like endoplasmic reticulum kinase
NP_001262282.1
NP_001262283.1
NP_649538.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5458563..5464753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141281.3 → NP_649538.1  pancreatic eIF-2alpha kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649538.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SX61, Q9NIV1, Q9VNB8
    Related
    FBpp0078417
    Conserved Domains (3) summary
    cd09768
    Location:73 → 401
    Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
    smart00220
    Location:925 → 1118
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:635 → 1113
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001275353.1 → NP_001262282.1  pancreatic eIF-2alpha kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262282.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGJ5
    Conserved Domains (3) summary
    cd09768
    Location:21 → 349
    Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
    smart00220
    Location:873 → 1066
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:583 → 1061
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001275354.1 → NP_001262283.1  pancreatic eIF-2alpha kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262283.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG56
    Conserved Domains (3) summary
    cd09768
    Location:10 → 338
    Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
    smart00220
    Location:862 → 1055
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:572 → 1050
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG56 A0A0B4KG56
A0A0B4KGJ5 A0A0B4KGJ5
Q9NIV1.2 Q9NIV1

Gene LinkOut

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