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orc5 origin recognition complex, subunit 5 [ Danio rerio (zebrafish) ]

Gene ID: 406479, updated on 27-Mar-2024

Summary

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Official Symbol
orc5provided by ZNC
Official Full Name
origin recognition complex, subunit 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2275
See related
Ensembl:ENSDARG00000021579 AllianceGenome:ZFIN:ZDB-GENE-040426-2275
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
orc5l; zgc:77827; wu:fb62d08
Summary
Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22347165..22379360, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (22632492..22658389, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene hematopoietic cell-specific Lyn substrate 1 Neighboring gene golgin B1 Neighboring gene uncharacterized LOC101884046 Neighboring gene guanylate cyclase activator 1Aa Neighboring gene LHFPL tetraspan subfamily member 3 Neighboring gene lysine (K)-specific methyltransferase 2E Neighboring gene NADH:ubiquinone oxidoreductase subunit B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Telomerase Is Essential for Zebrafish Heart Regeneration. Bednarek D, et al. Cell Rep, 2015 Sep 8. PMID 26321646, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of origin recognition complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213198.1 → NP_998363.1  origin recognition complex subunit 5

    See identical proteins and their annotated locations for NP_998363.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065383
    UniProtKB/TrEMBL
    A0A8M6Z5W8, Q6P0X9
    Related
    ENSDARP00000033056.4, ENSDART00000037670.5
    Conserved Domains (2) summary
    pfam13191
    Location:21 → 164
    AAA_16; AAA ATPase domain
    pfam14630
    Location:187 → 440
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    22347165..22379360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354991.2 → XP_017210480.1  origin recognition complex subunit 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5W8, Q6P0X9
    Conserved Domains (2) summary
    pfam13191
    Location:21 → 164
    AAA_16; AAA ATPase domain
    pfam14630
    Location:187 → 440
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

  2. XM_017354990.2 → XP_017210479.1  origin recognition complex subunit 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5W8, Q6P0X9
    Conserved Domains (2) summary
    pfam13191
    Location:21 → 164
    AAA_16; AAA ATPase domain
    pfam14630
    Location:187 → 440
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

  3. XM_017354989.2 → XP_017210478.1  origin recognition complex subunit 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5W8, Q6P0X9
    Conserved Domains (2) summary
    pfam13191
    Location:21 → 164
    AAA_16; AAA ATPase domain
    pfam14630
    Location:187 → 440
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

  4. XM_021474979.1 → XP_021330654.1  origin recognition complex subunit 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5W8, Q6P0X9
    Conserved Domains (2) summary
    pfam13191
    Location:21 → 164
    AAA_16; AAA ATPase domain
    pfam14630
    Location:187 → 440
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

  5. XM_021474980.1 → XP_021330655.1  origin recognition complex subunit 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5W8, Q6P0X9
    Conserved Domains (2) summary
    pfam13191
    Location:21 → 164
    AAA_16; AAA ATPase domain
    pfam14630
    Location:187 → 440
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus
Nucleotide Protein Strain
Heading Accession and Version

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