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orc4 origin recognition complex, subunit 4 [ Danio rerio (zebrafish) ]

Gene ID: 406462, updated on 11-Apr-2024

Summary

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Official Symbol
orc4provided by ZNC
Official Full Name
origin recognition complex, subunit 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2224
See related
Ensembl:ENSDARG00000101161 AllianceGenome:ZFIN:ZDB-GENE-040426-2224
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc50c03; zgc:85772; wu:fc50c03
Summary
Predicted to enable DNA replication origin binding activity. Acts upstream of or within cilium assembly. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (1748463..1762163, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (894094..907794, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene zgc:123305 Neighboring gene activin A receptor type 2Ab Neighboring gene zgc:158417 Neighboring gene zgc:113442

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors. Maerz LD, et al. Eur J Hum Genet, 2019 May. PMID 30696958, Free PMC Article
  2. Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors. Idilli AI, et al. Cancers (Basel), 2020 Apr 22. PMID 32331249, Free PMC Article
  3. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
  4. Telomerase Is Essential for Zebrafish Heart Regeneration. Bednarek D, et al. Cell Rep, 2015 Sep 8. PMID 26321646, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of origin recognition complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213183.1 → NP_998348.1  origin recognition complex subunit 4

    See identical proteins and their annotated locations for NP_998348.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067614
    UniProtKB/TrEMBL
    Q6NWF3
    Related
    ENSDARP00000130427.1, ENSDART00000171313.2
    Conserved Domains (3) summary
    smart00382
    Location:59 → 215
    AAA; ATPases associated with a variety of cellular activities
    pfam13191
    Location:34 → 188
    AAA_16; AAA ATPase domain
    pfam14629
    Location:226 → 403
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    1748463..1762163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168697.2 → XP_005168754.1  origin recognition complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BFZ9, F1QRE0
    Related
    ENSDARP00000141716.1, ENSDART00000167928.2
    Conserved Domains (3) summary
    smart00382
    Location:59 → 215
    AAA; ATPases associated with a variety of cellular activities
    pfam13191
    Location:34 → 188
    AAA_16; AAA ATPase domain
    pfam14629
    Location:226 → 403
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  2. XM_021476825.1 → XP_021332500.1  origin recognition complex subunit 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QFA6
    Conserved Domains (2) summary
    COG1474
    Location:31 → 214
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:226 → 281
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
Nucleotide Protein
Heading Accession and Version

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