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sumo1 small ubiquitin like modifier 1 [ Danio rerio (zebrafish) ]

Gene ID: 406438, updated on 27-Mar-2024

Summary

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Official Symbol
sumo1provided by ZNC
Official Full Name
small ubiquitin like modifier 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2186
See related
Ensembl:ENSDARG00000044267 AllianceGenome:ZFIN:ZDB-GENE-040426-2186
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fd12c02; zgc:65934; zgc:85634; hm:zeh0670; wu:fb74c02; wu:fd12c02
Summary
Predicted to enable protein tag and ubiquitin-like protein ligase binding activity. Acts upstream of or within chordate embryonic development and definitive hemopoiesis. Predicted to be located in nuclear stress granule. Predicted to be active in nucleus. Predicted to colocalize with PML body. Is expressed in brain; cranial neural crest cell; digestive system; eye; and pectoral fin bud. Human ortholog(s) of this gene implicated in orofacial cleft 10. Orthologous to human SUMO1 (small ubiquitin like modifier 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9677450..9688511)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9441911..9452972)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene transcription factor 23 Neighboring gene NOP58 ribonucleoprotein homolog (yeast) Neighboring gene frizzled class receptor 7b Neighboring gene cyclin-dependent kinase 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression analysis of small ubiquitin-like modifier (SUMO) genes from grouper (Epinephelus coioides). Xu M, et al. Fish Shellfish Immunol, 2016 Jan. PMID 26616235
  2. The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation. Pagano C, et al. Oncotarget, 2017 Jan 24. PMID 28008157, Free PMC Article
  3. Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish. Yuan H, et al. Cell Res, 2010 Feb. PMID 19704416
  4. Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Yuan H, et al. Sci Rep, 2015 Mar 11. PMID 25757417, Free PMC Article
  5. GATA5 SUMOylation is indispensable for zebrafish cardiac development. Wen B, et al. Biochim Biophys Acta Gen Subj, 2017 Jul. PMID 28285006

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to cadmium ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chordate embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within definitive hemopoiesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ubiquitin-related modifier 1
Names
SUMO-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213159.1 → NP_998324.1  small ubiquitin-related modifier 1

    See identical proteins and their annotated locations for NP_998324.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056283
    UniProtKB/Swiss-Prot
    Q7SZR5
    Related
    ENSDARP00000064994.5, ENSDART00000064995.6
    Conserved Domains (2) summary
    cd01763
    Location:10 → 96
    Sumo; Small ubiquitin-related modifier (SUMO)
    smart00213
    Location:21 → 92
    UBQ; Ubiquitin homologues

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    9677450..9688511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SZR5.1 GenPept UniProtKB/Swiss-Prot:Q7SZR5

Gene LinkOut

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