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rfc4 replication factor C (activator 1) 4 [ Danio rerio (zebrafish) ]

Gene ID: 406435, updated on 27-Mar-2024

Summary

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Official Symbol
rfc4provided by ZNC
Official Full Name
replication factor C (activator 1) 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040824-3
See related
Ensembl:ENSDARG00000042458 AllianceGenome:ZFIN:ZDB-GENE-040824-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rcf4; zgc:64030
Summary
Predicted to enable ATP binding activity and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Acts upstream of or within retina development in camera-type eye. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; immature eye; and nervous system. Orthologous to human RFC4 (replication factor C subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (45426607..45435006, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (45049041..45057440, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 13C Neighboring gene son of sevenless homolog 1 (Drosophila) Neighboring gene phospholipase A and acyltransferase 1 Neighboring gene gem (nuclear organelle) associated protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells. Kobayashi I, et al. Blood, 2010 Jan 14. PMID 19890097
  2. Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis. Fongang B, et al. PLoS One, 2016. PMID 27192554, Free PMC Article
  3. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
  4. Identification of zebrafish insertional mutants with defects in visual system development and function. Gross JM, et al. Genetics, 2005 May. PMID 15716491, Free PMC Article
  5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
replication factor C subunit 4
Names
replication factor C subunit RFC4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214737.2 → NP_999902.2  replication factor C subunit 4

    See identical proteins and their annotated locations for NP_999902.2

    Status: PROVISIONAL

    Source sequence(s)
    AY648805
    UniProtKB/TrEMBL
    Q6DRF4
    Related
    ENSDARP00000130135.1, ENSDART00000163923.2
    Conserved Domains (4) summary
    cd00009
    Location:50 → 196
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    PRK00440
    Location:34 → 346
    rfc; replication factor C small subunit; Reviewed
    pfam08542
    Location:281 → 348
    Rep_fac_C; Replication factor C C-terminal domain
    pfam16193
    Location:212 → 262
    AAA_assoc_2; AAA C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    45426607..45435006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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