ndufs8a NADH:ubiquinone oxidoreductase core subunit S8a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndufs8aprovided by ZNC
Official Full Name: NADH:ubiquinone oxidoreductase core subunit S8aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2153
See related: Ensembl:ENSDARG00000051986 AllianceGenome:ZFIN:ZDB-GENE-040426-2153
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ndufs8; zgc:65835; zgc:77840; wu:fb30b07
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity; metal ion binding activity; and oxidoreductase activity, acting on NAD(P)H. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in membrane. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (44814364..44823067)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (44113061..44121764)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: NADH:ubiquinone oxidoreductase core subunit S8a

Names: NADH dehydrogenase (ubiquinone) Fe-S protein 8, (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 8a; zgNADH dehydrogenase (ubiquinone) Fe-S protein 8, (NADH-coenzyme Q reductase)

NP_998304.1

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213139.1 → NP_998304.1 NADH:ubiquinone oxidoreductase core subunit S8a

See identical proteins and their annotated locations for NP_998304.1

Status: PROVISIONAL

Source sequence(s)

BC058299

UniProtKB/TrEMBL

F6P2X1, Q6P0T0, Q6PE39

Related

ENSDARP00000059226.4, ENSDART00000059227.5

Conserved Domains (2) summary

PRK05888
Location:54 → 210

PRK05888; NADH dehydrogenase subunit I; Provisional

pfam13187
Location:111 → 161

Fer4_9; 4Fe-4S dicluster domain