rhoaa ras homolog gene family, member Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rhoaaprovided by ZNC
Official Full Name: ras homolog gene family, member Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2150
See related: Ensembl:ENSDARG00000026845 AllianceGenome:ZFIN:ZDB-GENE-040426-2150
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Rhoa; zgc:66058; zgc:85805; wu:fa66g04; wu:fb26g07
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be located in membrane. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and neuron projection. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (14170571..14179798, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (14132866..14142093, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.
Title: Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fe02e11.x1 (e-PCR)
- UniSTS:195942

fk48e03.x1 (e-PCR)
- UniSTS:201064

fa66g04 (e-PCR)
- UniSTS:188847

AI444388 (e-PCR)
- UniSTS:206565

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle satellite cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of cells	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: rho-related GTP-binding protein RhoA-A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213137.1 → NP_998302.1 rho-related GTP-binding protein RhoA-A

See identical proteins and their annotated locations for NP_998302.1

Status: PROVISIONAL

Source sequence(s)

BC056556

UniProtKB/Swiss-Prot

Q6NUX8

Related

ENSDARP00000040644.6, ENSDART00000040645.8

Conserved Domains (2) summary

smart00174
Location:8 → 181

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC