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Prosbeta7 Proteasome beta7 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40639, updated on 5-May-2024

Summary

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Official Symbol
Prosbeta7provided by FlyBase
Official Full Name
Proteasome beta7 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0250746
Locus tag
Dmel_CG12000
See related
AllianceGenome:FB:FBgn0250746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12000; 154275_at; anon-WO0118547.326; beta-4; beta-7; Beta-7; beta7; CG12000; Dmel\CG12000; GC12000; Prosbeta4; Prot. beta4
Summary
Predicted to enable threonine-type endopeptidase activity. Involved in centrosome cycle. Part of proteasome core complex. Is expressed in adult head and organism. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
82F11-82F11; 3-47.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5357012..5358364, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1182734..1184086, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ceramide kinase Neighboring gene long non-coding RNA:CR44103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteasome Structure and Assembly. Budenholzer L, et al. J Mol Biol, 2017 Nov 10. PMID 28583440, Free PMC Article
  2. Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man. Adrain C, et al. J Biol Chem, 2004 Aug 27. PMID 15210720
  3. The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila. Lu C, et al. Development, 2013 Sep. PMID 23884444, Free PMC Article
  4. Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster. Järvelä-Stölting M, et al. Front Immunol, 2021. PMID 35003057, Free PMC Article
  5. The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development. Wang CH, et al. Biochem Biophys Res Commun, 2014 Sep 26. PMID 25152394

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome beta7 subunit
Names
CG12000-PA
CG12000-PB
Prosbeta4
Prosbeta7-PA
Prosbeta7-PB
beta-type 4 subunit
beta7
proteasome beta4 subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5357012..5358364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141272.1 → NP_649529.1  proteasome beta7 subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649529.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2F4, Q9VNA5
    Related
    FBpp0078448, FBtr0078805
    Conserved Domains (2) summary
    COG0638
    Location:60 → 232
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03760
    Location:60 → 252
    proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

  2. NM_169049.2 → NP_730922.1  proteasome beta7 subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730922.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2F4, Q9VNA5
    Related
    FBpp0078449
    Conserved Domains (2) summary
    COG0638
    Location:60 → 232
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03760
    Location:60 → 252
    proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNA5.1 Q9VNA5

Gene LinkOut

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