U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pla2g6 phospholipase A2, group VI (cytosolic, calcium-independent) [ Danio rerio (zebrafish) ]

Gene ID: 406370, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
pla2g6provided by ZNC
Official Full Name
phospholipase A2, group VI (cytosolic, calcium-independent)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2079
See related
Ensembl:ENSDARG00000060921 AllianceGenome:ZFIN:ZDB-GENE-040426-2079
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77476; wu:fc06g09
Summary
Predicted to enable calcium-independent phospholipase A2 activity and palmitoyl-CoA hydrolase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and positive regulation of ceramide biosynthetic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including eye; heart; liver; muscle; and ovary. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pla2g6 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (29087372..29126878)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (29138202..29177683)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 100 Neighboring gene chromobox homolog 6a Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2b Neighboring gene parvalbumin 7 Neighboring gene neutrophil cytosolic factor 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models. Yeh TH, et al. Exp Neurol, 2021 Dec. PMID 34520727
  2. Chlorella diet alters mitochondrial cardiolipin contents differentially in organs of Danio rerio analyzed by a lipidomics approach. Chao YJ, et al. PLoS One, 2018. PMID 29494608, Free PMC Article
  3. Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. Miller GW, et al. J Nutr Biochem, 2012 May. PMID 21684137, Free PMC Article
  4. Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Wang D, et al. J Hazard Mater, 2021 Jul 5. PMID 33621777
  5. Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Sánchez E, et al. Mol Neurobiol, 2018 Aug. PMID 29344929

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pla2g6 deficiency resulted in axonal degeneration, dopaminergic and motor neuron cell loss, and increased beta-synuclein expression.
    Title: Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
85/88 kDa calcium-independent phospholipase A2
NP_998262.1
XP_005161851.1
XP_021324984.1
XP_021324985.1
XP_021324986.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213097.2 → NP_998262.1  85/88 kDa calcium-independent phospholipase A2

    See identical proteins and their annotated locations for NP_998262.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067375
    UniProtKB/TrEMBL
    Q6NWY0
    Related
    ENSDARP00000044558.4, ENSDART00000044559.6
    Conserved Domains (5) summary
    cd07212
    Location:467 → 805
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:145 → 271
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:155 → 247
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:120 → 171
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:151 → 182
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    29087372..29126878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161794.3 → XP_005161851.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B8Y5, F1QXU0
    Related
    ENSDARP00000155190.1, ENSDART00000186776.1
    Conserved Domains (5) summary
    cd07212
    Location:467 → 805
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:145 → 271
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:155 → 247
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:120 → 171
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:151 → 182
    ANK; ANK repeat [structural motif]

  2. XM_021469309.1 → XP_021324984.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PJI1
    Related
    ENSDARP00000125120.1, ENSDART00000150489.3
    Conserved Domains (3) summary
    cd07212
    Location:473 → 811
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:151 → 277
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]

  3. XM_021469311.1 → XP_021324986.1  85/88 kDa calcium-independent phospholipase A2 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PRQ9
    Conserved Domains (3) summary
    cd07212
    Location:434 → 772
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:151 → 277
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]

  4. XM_021469310.1 → XP_021324985.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PV82
    Conserved Domains (3) summary
    cd07212
    Location:473 → 786
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:151 → 277
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395117.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    53464..98846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.