sucla2 succinate-CoA ligase ADP-forming subunit beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sucla2provided by ZNC
Official Full Name: succinate-CoA ligase ADP-forming subunit betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1963
See related: Ensembl:ENSDARG00000005359 AllianceGenome:ZFIN:ZDB-GENE-040426-1963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73397; wu:fb18c11; wu:fj38c11; wu:fj90d07
Summary: Predicted to enable succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including axis; hatching gland; mesoderm; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (10037273..10056640)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (9801734..9821101)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb18c11.x1 (e-PCR)
- UniSTS:203009

fj90d07.x1 (e-PCR)
- UniSTS:200276

fj38c11.x1 (e-PCR)
- UniSTS:199256

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables succinate-CoA ligase (ADP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (ADP-forming) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in succinyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of succinate-CoA ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

Names: succinate-CoA ligase, ADP-forming, beta subunit

NP_998191.1

EC 6.2.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213026.1 → NP_998191.1 succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

See identical proteins and their annotated locations for NP_998191.1

Status: PROVISIONAL

Source sequence(s)

BC059701

UniProtKB/TrEMBL

A0A8M1PIK4, Q6PBI0

Related

ENSDARP00000021652.7, ENSDART00000018503.9

Conserved Domains (3) summary

PRK00696
Location:58 → 448

sucC; succinyl-CoA synthetase subunit beta; Provisional

pfam00549
Location:324 → 444

Ligase_CoA; CoA-ligase

pfam08442
Location:58 → 265

ATP-grasp_2; ATP-grasp domain