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Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 406165, updated on 3-Apr-2024

Summary

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Official Symbol
Agpat1provided by RGD
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 1provided by RGD
Primary source
RGD:1303287
See related
Ensembl:ENSRNOG00000000437 AllianceGenome:RGD:1303287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process and positive regulation of cytokine production. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 171.6), Testes (RPKM 109.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4140565..4149531, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4135955..4144880, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4369399..4378272)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase like Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene ring finger protein 5 Neighboring gene advanced glycosylation end product-specific receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. Aguado B, et al. J Biol Chem, 1998 Feb 13. PMID 9461603
  2. cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Kume K, et al. Biochem Biophys Res Commun, 1997 Aug 28. PMID 9299423
  3. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. West J, et al. DNA Cell Biol, 1997 Jun. PMID 9212163
  4. Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice. Agarwal AK, et al. J Biol Chem, 2011 Oct 28. PMID 21873652, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94573

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Names
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
NP_997623.1
XP_006256036.1
XP_006256037.1
XP_038954860.1
XP_063135419.1
XP_063135420.1
XP_063135422.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212458.1 → NP_997623.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

    See identical proteins and their annotated locations for NP_997623.1

    Status: VALIDATED

    Source sequence(s)
    BX883044
    UniProtKB/TrEMBL
    A6KTH1, Q5U2V3, Q6MG85
    Conserved Domains (1) summary
    cd07989
    Location:66 → 252
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4140565..4149531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279352.1 → XP_063135422.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

    UniProtKB/TrEMBL
    F7EQT9

  2. XM_006255974.3 → XP_006256036.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2

    See identical proteins and their annotated locations for XP_006256036.1

    UniProtKB/TrEMBL
    A6KTH1, Q5U2V3, Q6MG85
    Conserved Domains (1) summary
    cd07989
    Location:66 → 252
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  3. XM_063279349.1 → XP_063135419.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

    UniProtKB/TrEMBL
    F7EQT9

  4. XM_039098932.2 → XP_038954860.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2

    UniProtKB/TrEMBL
    A6KTH1, Q5U2V3, Q6MG85
    Conserved Domains (1) summary
    cd07989
    Location:66 → 252
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  5. XM_063279350.1 → XP_063135420.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

    UniProtKB/TrEMBL
    F7EQT9

  6. XM_006255975.3 → XP_006256037.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2

    See identical proteins and their annotated locations for XP_006256037.1

    UniProtKB/TrEMBL
    A6KTH1, Q5U2V3, Q6MG85
    Conserved Domains (1) summary
    cd07989
    Location:66 → 252
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Nucleotide Protein Strain
Heading Accession and Version

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