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Gnf1 Germ line transcription factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40607, updated on 4-Apr-2024

Summary

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Official Symbol
Gnf1provided by FlyBase
Official Full Name
Germ line transcription factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0004913
Locus tag
Dmel_CG1119
See related
AllianceGenome:FB:FBgn0004913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1119; Dmel\CG1119; DmRFC1; dRF-Cp140; dRFC140; Gnf-1; gnf1; GTF-1; gtf1; Gtf1; ONF-CAACAA; RF-C 140; RfC; RFC; rfc1; RFC1; RfC140; RFC140
Summary
Enables DNA binding activity. Involved in dendrite morphogenesis. Located in nucleus. Is expressed in several structures, including CNS glial cell; adult head; extended germ band embryo; and lateral cord neurons. Human ortholog(s) of this gene implicated in West Nile fever. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Gnf1 in Genome Data Viewer
Location:
82E2-82E2; 3-47.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4906622..4910081)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (732344..735803)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene labial associated factor Neighboring gene long non-coding RNA:CR45580 Neighboring gene Chondrocyte-derived ezrin-like domain containing protein Neighboring gene long non-coding RNA:CR45188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and characterization of an active N-acetylglucosaminyltransferase enzyme complex from Streptococci. Wu R, et al. Appl Environ Microbiol, 2010 Dec. PMID 20971868, Free PMC Article
  2. Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA. Keller RC, et al. Nucleic Acids Res, 1999 Sep 1. PMID 10446230, Free PMC Article
  3. DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C. Allen BL, et al. Nucleic Acids Res, 1998 Sep 1. PMID 9705493, Free PMC Article
  4. Identification and characterization of Drosophila female germ line transcriptional control elements. Frank LH, et al. Development, 1992 Feb. PMID 1592002
  5. Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. Mossi R, et al. J Biol Chem, 1997 Jan 17. PMID 8999859

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication factor C complex IEA
Inferred from Electronic Annotation
more info
  
part_of DNA replication factor C complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
germ line transcription factor 1
Names
CG1119-PA
CG1119-PB
Gnf1-PA
Gnf1-PB
Replication-factor-C 140kD subunit
germline transcription factor
replication factor C 140kD subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4906622..4910081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014605.3 → NP_001014605.1  germ line transcription factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014605.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35600
    Conserved Domains (5) summary
    COG5275
    Location:151 → 358
    COG5275; BRCT domain type II [General function prediction only]
    PRK04195
    Location:421 → 969
    PRK04195; replication factor C large subunit; Provisional
    pfam00004
    Location:506 → 633
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam00533
    Location:232 → 309
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam08519
    Location:764 → 917
    RFC1; Replication factor RFC1 C terminal domain

  2. NM_079505.3 → NP_524229.1  germ line transcription factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524229.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02031, P35600, Q8MR76
    Related
    FBpp0078478
    Conserved Domains (6) summary
    COG5275
    Location:151 → 358
    COG5275; BRCT domain type II [General function prediction only]
    PRK04195
    Location:421 → 947
    PRK04195; replication factor C large subunit; Provisional
    pfam00004
    Location:484 → 611
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam00533
    Location:232 → 309
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam08519
    Location:742 → 895
    RFC1; Replication factor RFC1 C terminal domain
    cl19912
    Location:605 → 657
    DNA_pol3_delta; DNA polymerase III, delta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35600.2 P35600

Gene LinkOut

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