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cdk7 cyclin-dependent kinase 7 [ Danio rerio (zebrafish) ]

Gene ID: 405897, updated on 11-Apr-2024

Summary

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Official Symbol
cdk7provided by ZNC
Official Full Name
cyclin-dependent kinase 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-010320-2
See related
Ensembl:ENSDARG00000051916 AllianceGenome:ZFIN:ZDB-GENE-010320-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:85821
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in phosphorylation of RNA polymerase II C-terminal domain and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within phosphorylation. Predicted to be part of transcription factor TFIIK complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (52000159..52010153, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (51353458..51363565, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene thrombospondin 4a Neighboring gene serine incorporator 5 Neighboring gene si:ch211-198e13.3 Neighboring gene SET binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo. Hoodless LJ, et al. Sci Rep, 2016 Nov 11. PMID 27833165, Free PMC Article
  2. Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone. Kondo T, et al. Dev Biol, 1997 Oct 1. PMID 9331337
  3. Developmental expression of cyclin H and Cdk7 in zebrafish: the essential role of cyclin H during early embryo development. Liu QY, et al. Cell Res, 2007 Feb. PMID 17287831
  4. The zebrafish miR-125c is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations and embryogenesis. He Y, et al. Oncotarget, 2017 Sep 26. PMID 29088751, Free PMC Article
  5. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Silva IA, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 Jun-Jul. PMID 24731924

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC85821

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIK complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 7
NP_998126.2
XP_005165728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212961.2 → NP_998126.2  cyclin-dependent kinase 7

    See identical proteins and their annotated locations for NP_998126.2

    Status: PROVISIONAL

    Source sequence(s)
    DQ294347
    UniProtKB/TrEMBL
    A0A8M1PG21, Q2V6H0
    Related
    ENSDARP00000051002.4, ENSDART00000051003.6
    Conserved Domains (2) summary
    PTZ00024
    Location:7 → 308
    PTZ00024; cyclin-dependent protein kinase; Provisional
    cd07841
    Location:11 → 308
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    52000159..52010153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165671.4 → XP_005165728.1  cyclin-dependent kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_005165728.1

    UniProtKB/TrEMBL
    A0A8M2BD11, Q6NWC5
    Related
    ENSDARP00000068117.4, ENSDART00000073627.6
    Conserved Domains (2) summary
    PTZ00024
    Location:7 → 274
    PTZ00024; cyclin-dependent protein kinase; Provisional
    cd07841
    Location:11 → 274
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
Nucleotide Protein Strain
Heading Accession and Version

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