nlk1 nemo-like kinase, type 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nlk1provided by ZNC
Official Full Name: nemo-like kinase, type 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040701-1
See related: Ensembl:ENSDARG00000006566 AllianceGenome:ZFIN:ZDB-GENE-040701-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nlk; nlkb; zgc:111875
Summary: Predicted to enable MAP kinase activity. Acts upstream of or within negative regulation of Notch signaling pathway; positive regulation of Wnt signaling pathway; and positive regulation of neurogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including eye; immature eye; neural plate; notochord; and otic vesicle. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (21067824..21094468, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (20918084..20944728, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nanog suppresses the expression of vasa by directly regulating nlk1 in the early zebrafish embryo
Title: Nanog suppresses the expression of vasa by directly regulating nlk1 in the early zebrafish embryo.
NLK negatively regulates Notch-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.
Title: Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.
nlk strongly enhances convergent/extension phenotypes, suggesting a role in modulating cell movements as well as cell fate.
Title: nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nemo-like kinase, type 1

Names: nemo like kinase b

NP_998121.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212956.2 → NP_998121.1 nemo-like kinase, type 1

See identical proteins and their annotated locations for NP_998121.1

Status: VALIDATED

Source sequence(s)

CU914481

UniProtKB/TrEMBL

A0A8M1PG17, Q6Q382

Related

ENSDARP00000100637.2, ENSDART00000109790.5

Conserved Domains (2) summary

cd07853
Location:87 → 458

STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

smart00220
Location:89 → 377

S_TKc; Serine/Threonine protein kinases, catalytic domain