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trib3 tribbles pseudokinase 3 [ Danio rerio (zebrafish) ]

Gene ID: 405805, updated on 27-Mar-2024

Summary

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Official Symbol
trib3provided by ZNC
Official Full Name
tribbles pseudokinase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2609
See related
Ensembl:ENSDARG00000016200 AllianceGenome:ZFIN:ZDB-GENE-040426-2609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:76966
Summary
Predicted to enable mitogen-activated protein kinase kinase binding activity. Acts upstream of or within heart looping. Predicted to be active in nucleus. Is expressed in several structures, including axial mesoderm; central nervous system; intestine; noninvoluting endocytic marginal cell cluster; and notochord. Orthologous to human TRIB3 (tribbles pseudokinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See trib3 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24058530..24063196, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (23820673..23825339, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 11A Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III a Neighboring gene uncharacterized LOC101886364 Neighboring gene SRY-box transcription factor 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tribbles: a family of kinase-like proteins with potent signalling regulatory function. Hegedus Z, et al. Cell Signal, 2007 Feb. PMID 16963228
  2. Tribbles: novel regulators of cell function; evolutionary aspects. Hegedus Z, et al. Cell Mol Life Sci, 2006 Jul. PMID 16715410
  3. The Sec domain protein Scfd1 facilitates trafficking of ECM components during chondrogenesis. Hou N, et al. Dev Biol, 2017 Jan 1. PMID 27851892
  4. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Gut P, et al. Nat Chem Biol, 2013 Feb. PMID 23201900, Free PMC Article
  5. Genome-wide identification of novel long non-coding RNAs and their possible roles in hypoxic zebrafish brain. Banerjee B, et al. Genomics, 2021 Jan. PMID 33264657

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC76966

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tribbles homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212869.1 → NP_998034.1  tribbles homolog 3

    See identical proteins and their annotated locations for NP_998034.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066744
    UniProtKB/TrEMBL
    Q6NY44
    Related
    ENSDARP00000036401.7, ENSDART00000036513.9
    Conserved Domains (2) summary
    smart00220
    Location:82 → 314
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14024
    Location:73 → 314
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    24058530..24063196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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