grem1a gremlin 1a, DAN family BMP antagonist [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grem1aprovided by ZNC
Official Full Name: gremlin 1a, DAN family BMP antagonistprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-1
See related: Ensembl:ENSDARG00000029546 AllianceGenome:ZFIN:ZDB-GENE-040625-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grem1; zgc:136702
Summary: Predicted to enable BMP binding activity and receptor ligand activity. Predicted to be involved in animal organ morphogenesis and sequestering of BMP from receptor via BMP binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cranial vault; notochord; pectoral fin bud; pronephric duct; and segmental plate. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (29469753..29471577, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (29566874..29568698, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a.
Title: FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway.
Results suggest that the negative regulatory loops between BMP/Tbx2 and Gremlin or Hey1 are responsible for defining the territory of the pronephric nephron.
Title: Role of Tbx2 in defining the territory of the pronephric nephron.
Gremlin encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition.
Title: Regulated expression pattern of gremlin during zebrafish development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of BMP from receptor via BMP binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gremlin-1a

Names: gremlin 1 homolog a, cysteine knot superfamily; gremlin 1 homolog, cysteine knot superfamily

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.