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EGFR epidermal growth factor receptor [ Canis lupus familiaris (dog) ]

Gene ID: 404306, updated on 11-Apr-2024

Summary

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Official Symbol
EGFRprovided by VGNC
Official Full Name
epidermal growth factor receptorprovided by VGNC
Primary source
VGNC:VGNC:51866
See related
Ensembl:ENSCAFG00845011396
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (5890289..6087722)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (5693578..5890886)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (5960845..6158207)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (5880554..6077776)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (5854700..6051915)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U3 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC102151152 Neighboring gene uncharacterized LOC119864155 Neighboring gene uncharacterized LOC119864156 Neighboring gene uncharacterized LOC111090863 Neighboring gene uncharacterized LOC111090798 Neighboring gene U6 spliceosomal RNA Neighboring gene LanC like glutathione S-transferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR. Patil PU, et al. J Cell Sci, 2015 Dec 1. PMID 26483386, Free PMC Article
  2. Epidermal growth factor receptor expression in canine transitional cell carcinoma. Hanazono K, et al. J Vet Med Sci, 2015 Jan. PMID 25223345, Free PMC Article
  3. EGFR overexpression in canine primary lung cancer: pathogenetic implications and impact on survival. Sabattini S, et al. Vet Comp Oncol, 2014 Sep. PMID 22994149
  4. Immunohistochemical expression of Epidermal Growth Factor Receptor (EGFR) in canine mammary tissues. Gama A, et al. Res Vet Sci, 2009 Dec. PMID 19464036
  5. Canine oocyte maturation in culture: significance of estrogen and EGF receptor gene expression in cumulus cells. Hatoya S, et al. Theriogenology, 2009 Mar 1. PMID 19101024

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
    Title: EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
  2. Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation.
    Title: Canine parvovirus induces G1/S cell cycle arrest that involves EGFR Tyr1086 phosphorylation.
  3. Significant EGFR and HER-2 mRNA and protein expressions in in situ carcinomatous sites relative to invasive areas suggest that these molecules play a role during the early stages of tumor progression.
    Title: HER-2 and EGFR mRNA Expression and Its Relationship with Versican in Malignant Matrix-Producing Tumors of the Canine Mammary Gland.
  4. epidermal growth factor, transforming growth factor-alpha and EGF receptor may be involved in testicular maturation and function in the dog
    Title: Expression and localization of epidermal growth factor, transforming growth factor-α and epidermal growth factor receptor in the canine testis.
  5. results, for the first time, demonstrate that carcinoma cells can induce sE-cad shedding in adjacent epithelial cells, which leads to EGFR activation and the eventual transdifferentiation of the normal epithelial cells.
    Title: Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR.
  6. These findings suggest that intense expression of EGFR protein could be used as a marker to help canine transitional cell carcinoma diagnosis.
    Title: Epidermal growth factor receptor expression in canine transitional cell carcinoma.
  7. The present results suggest that the COX-2(+)/EGFR(+) status may be part of a strategy adopted by tumor cells to evade the cytotoxic tumor-specific immune responses
    Title: Positive Interplay Between CD3+ T-lymphocytes and Concurrent COX-2/EGFR Expression in Canine Malignant Mammary Tumors.
  8. These findings suggest an involvement of EGFR signalling pathway in canine primary lung cancer, a negative prognostic significance of protein overexpression and its potential implication in air pollution carcinogenesis.
    Title: EGFR overexpression in canine primary lung cancer: pathogenetic implications and impact on survival.
  9. In canine malignant mammary tumors, high EGRF immunoreactivity was associated with tumour size, necrosis, mitotic index, histological grade of malignancy and lymph node metastasis.
    Title: Concurrent expression of cyclo-oxygenase-2 and epidermal growth factor receptor in canine malignant mammary tumours.
  10. Through its IQ motifs, IQGAP1 binds to EGFR, which is responsible for maintaining IQGAP1 in the basolateral membrane domain.
    Title: EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor
Names
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
XP_038279602.1
XP_038279603.1
XP_038279604.1
XP_038309644.1
XP_038309646.1
XP_038309647.1
XP_038355969.1
XP_038355970.1
XP_038355971.1
XP_038418551.1
XP_038418552.1
XP_038418553.1
XP_038482631.1
XP_038482632.1
XP_038482633.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    5890289..6087722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038423674.1 → XP_038279602.1  epidermal growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8C0RE23, A0A8I3RYJ5
    Related
    ENSCAFP00845015889.1, ENSCAFT00845020269.1
    Conserved Domains (5) summary
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:634 → 677
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:185 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_038423676.1 → XP_038279604.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIX3, A0A8D6L9C2
    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_038423675.1 → XP_038279603.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIX3, A0A8D6L9C2
    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    5880554..6077776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038500041.1 → XP_038355969.1  epidermal growth factor receptor isoform X1

    Conserved Domains (5) summary
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:634 → 677
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:185 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_038500043.1 → XP_038355971.1  epidermal growth factor receptor isoform X2

    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_038500042.1 → XP_038355970.1  epidermal growth factor receptor isoform X2

    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    5854700..6051915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038626703.1 → XP_038482631.1  epidermal growth factor receptor isoform X1

    Conserved Domains (5) summary
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:634 → 677
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:185 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_038626705.1 → XP_038482633.1  epidermal growth factor receptor isoform X2

    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_038626704.1 → XP_038482632.1  epidermal growth factor receptor isoform X2

    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    5960845..6158207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038562623.1 → XP_038418551.1  epidermal growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8C0RE23, A0A8I3RYJ5
    Conserved Domains (5) summary
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:634 → 677
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:185 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_038562625.1 → XP_038418553.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIX3, A0A8D6L9C2
    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_038562624.1 → XP_038418552.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIX3, A0A8D6L9C2
    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    5693578..5890886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038453716.1 → XP_038309644.1  epidermal growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8C0RE23, A0A8I3RYJ5
    Conserved Domains (5) summary
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:634 → 677
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:185 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_038453719.1 → XP_038309647.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIX3, A0A8D6L9C2
    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_038453718.1 → XP_038309646.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIX3, A0A8D6L9C2
    Conserved Domains (5) summary
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:581 → 624
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 584
    GF_recep_IV; Growth factor receptor domain IV
Nucleotide Protein
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