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CycH Cyclin H [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40429, updated on 4-Apr-2024

Summary

Official Symbol
CycHprovided by FlyBase
Official Full Name
Cyclin Hprovided by FlyBase
Primary source
FLYBASE:FBgn0022936
Locus tag
Dmel_CG7405
See related
AllianceGenome:FB:FBgn0022936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
142767_at; CCNH; CG7405; Dmel\CG7405
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of cyclin-dependent protein serine/threonine kinase activity and transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:
78F3-78F3; 3-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21821997..21823309)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21815097..21816409)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45958 Neighboring gene eagle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of carboxy-terminal domain protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIIH holo complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIIK complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclin H
Names
CG7405-PA
CycH-PA
CyclinH
cyclin-H

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21821997..21823309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079483.3NP_524207.1  cyclin H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76513, Q32KG2
    Related
    FBpp0078093
    Conserved Domains (3) summary
    TIGR00569
    Location:2307
    ccl1; cyclin ccl1
    cd00043
    Location:63127
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam16899
    Location:159257
    Cyclin_C_2; Cyclin C-terminal domain