crim1 cysteine rich transmembrane BMP regulator 1 (chordin-like) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crim1provided by ZNC
Official Full Name: cysteine rich transmembrane BMP regulator 1 (chordin-like)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040312-2
See related: Ensembl:ENSDARG00000029668 AllianceGenome:ZFIN:ZDB-GENE-040312-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc29f08
Summary: Predicted to enable insulin-like growth factor binding activity and serine-type endopeptidase inhibitor activity. Acts upstream of or within blood vessel development; notochord morphogenesis; and somitogenesis. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; intermediate cell mass of mesoderm; notochord; otic vesicle; and posterior segment eye. Used to study cataract and microphthalmia. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (38929275..39184408, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (38981690..39236823, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development
Title: Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development.

Submit: New GeneRIF Correction

General gene information

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Markers

fc47e04.y1 (e-PCR)
- UniSTS:193965

fc29f08.x1 (e-PCR)
- UniSTS:193460

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cysteine-rich motor neuron 1 protein

Names: CRIM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212821.1 → NP_997986.1 cysteine-rich motor neuron 1 protein precursor

See identical proteins and their annotated locations for NP_997986.1

Status: PROVISIONAL

Source sequence(s)

AY151045

UniProtKB/Swiss-Prot

Q7T3Q2

Related

ENSDARP00000050533.4, ENSDART00000050534.6

Conserved Domains (4) summary

smart00214
Location:330 → 384

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:33 → 84

IGFBP; Insulin-like growth factor binding protein

pfam02822
Location:561 → 586

Antistasin; Antistasin family

cl17735
Location:812 → 866

VWC; von Willebrand factor type C domain