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Cyp2c54 cytochrome P450, family 2, subfamily c, polypeptide 54 [ Mus musculus (house mouse) ]

Gene ID: 404195, updated on 11-Apr-2024

Summary

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Official Symbol
Cyp2c54provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily c, polypeptide 54provided by MGI
Primary source
MGI:MGI:3642960
See related
Ensembl:ENSMUSG00000067225 AllianceGenome:MGI:3642960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG404195
Summary
Enables arachidonic acid epoxygenase activity and linoleic acid epoxygenase activity. Acts upstream of or within arachidonic acid metabolic process and linoleic acid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; eosinophilic esophagitis; glucose metabolism disease (multiple); invasive aspergillosis; and multiple chemical sensitivity. Orthologous to human CYP2C19 (cytochrome P450 family 2 subfamily C member 19) and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 103.0) See more
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Genomic context

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See Cyp2c54 in Genome Data Viewer
Location:
19 C3; 19 34.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (40026383..40062289, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (40037939..40073845, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 71, pseudogene Neighboring gene STARR-seq mESC enhancer starr_46124 Neighboring gene STARR-seq mESC enhancer starr_46125 Neighboring gene cytochrome P450, family 2. subfamily c, polypeptide 37 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 50 Neighboring gene STARR-seq mESC enhancer starr_46126 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. Wang H, et al. Mol Pharmacol, 2004 May. PMID 15102943
  2. Emergence of complex rearrangements at translocation breakpoints in a transgenic mouse; implications for mechanisms involved in the formation of chromosome rearrangements. Kasai F, et al. Cytogenet Genome Res, 2007. PMID 18160786
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables linoleic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 2C54
Names
CYPIIC54
NP_996260.1
XP_006527235.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206537.2 → NP_996260.1  cytochrome P450 2C54

    See identical proteins and their annotated locations for NP_996260.1

    Status: VALIDATED

    Source sequence(s)
    AI046359, AI047349, AI181879, BF659738
    Consensus CDS
    CCDS29800.1
    UniProtKB/Swiss-Prot
    Q6XVG2
    UniProtKB/TrEMBL
    Q9DBD9
    Related
    ENSMUSP00000048284.4, ENSMUST00000048959.5
    Conserved Domains (1) summary
    pfam00067
    Location:30 → 487
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    40026383..40062289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527172.2 → XP_006527235.1  cytochrome P450 2C54 isoform X1

    UniProtKB/TrEMBL
    Q9DBD9
    Conserved Domains (1) summary
    pfam00067
    Location:30 → 428
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6XVG2.1 GenPept UniProtKB/Swiss-Prot:Q6XVG2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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