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papola poly(A) polymerase alpha [ Danio rerio (zebrafish) ]

Gene ID: 404041, updated on 11-Apr-2024

Summary

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Official Symbol
papolaprovided by ZNC
Official Full Name
poly(A) polymerase alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3507
See related
Ensembl:ENSDARG00000009585 AllianceGenome:ZFIN:ZDB-GENE-030131-3507
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
papolb; wu:fc43b06; wu:fp01g10; zgc:109706; si:ch211-199l3.6
Summary
Predicted to enable polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to act upstream of or within RNA 3'-end processing; RNA polyadenylation; and mRNA processing. Predicted to be active in nucleus. Orthologous to human PAPOLA (poly(A) polymerase alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See papola in Genome Data Viewer
Location:
chromosome: 20
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (4712776..4738141, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (4669863..4695228, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene claudin-20 Neighboring gene BCL11 transcription factor B b Neighboring gene adenylate kinase 7a Neighboring gene galactosylceramidase a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Zhou S, et al. Fish Shellfish Immunol, 2016 Feb. PMID 26767746
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109706

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
poly(A) polymerase alpha
Names
poly(A) polymerase beta (testis specific)
NP_991321.2
XP_005160406.1
XP_009292816.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205758.2 → NP_991321.2  poly(A) polymerase alpha

    Status: PROVISIONAL

    Source sequence(s)
    AL953887
    UniProtKB/TrEMBL
    A0A8M1PF15, Q5SNY2
    Related
    ENSDARP00000053857.5, ENSDART00000053858.7
    Conserved Domains (3) summary
    PTZ00418
    Location:7 → 561
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:365 → 494
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:20 → 362
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    4712776..4738141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294541.1 → XP_009292816.1  poly(A) polymerase alpha isoform X2

    UniProtKB/TrEMBL
    A0A8M3AT08
    Conserved Domains (3) summary
    PTZ00418
    Location:7 → 561
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:365 → 494
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:20 → 362
    PAP_central; Poly(A) polymerase central domain

  2. XM_005160349.1 → XP_005160406.1  poly(A) polymerase alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M2B770
    Conserved Domains (3) summary
    PTZ00418
    Location:7 → 561
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:365 → 494
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:20 → 362
    PAP_central; Poly(A) polymerase central domain
Nucleotide Protein Strain
Heading Accession and Version

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