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RAB5A RAB5A, member RAS oncogene family [ Canis lupus familiaris (dog) ]

Gene ID: 404008, updated on 5-Mar-2024

Summary

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Official Symbol
RAB5Aprovided by VGNC
Official Full Name
RAB5A, member RAS oncogene familyprovided by VGNC
Primary source
VGNC:VGNC:45291
See related
Ensembl:ENSCAFG00845021204
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (23790486..23820520, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (23330152..23357439, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (23815500..23842853, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (23503982..23531284, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (23569385..23596703, complement)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene shugoshin 1 Neighboring gene lysine acetyltransferase 2B Neighboring gene uncharacterized LOC119865372 Neighboring gene protein phosphatase 2C like domain containing 1 Neighboring gene uncharacterized LOC119865373 Neighboring gene EF-hand domain family member B Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Continual expression of Rab5(Q79L) causes a ligand-independent EGFR internalization and diminishes EGFR activity. Dinneen JL, et al. Traffic, 2004 Aug. PMID 15260830
  2. Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Stenmark H, et al. Cell, 1995 Nov 3. PMID 8521472
  3. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Chavrier P, et al. Cell, 1990 Jul 27. PMID 2115402
  4. Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin. Kimura T, et al. J Biol Chem, 2006 Apr 14. PMID 16423831
  5. Sec14 homology domain targets p50RhoGAP to endosomes and provides a link between Rab and Rho GTPases. Sirokmány G, et al. J Biol Chem, 2006 Mar 3. PMID 16380373

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab5 regulates and coordinates different endocytic mechanisms through its effector Rabankyrin-5
    Title: The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.
  2. Data show that rab5 activation regulates epidermal growth factor receptor (EGFR) signaling by facilitating the internalization of the unliganded EGFR.
    Title: Continual expression of Rab5(Q79L) causes a ligand-independent EGFR internalization and diminishes EGFR activity.
  3. RIN2 connects Ras to Rab5 in the HGF-induced endocytosis of E-cadherin [RIN2]
    Title: Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ras-related protein Rab-5A
Names
GTP-binding protein (rab5)
NP_001003317.1
XP_038287515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003317.2 → NP_001003317.1  ras-related protein Rab-5A

    See identical proteins and their annotated locations for NP_001003317.1

    Status: PROVISIONAL

    Source sequence(s)
    M35520
    UniProtKB/Swiss-Prot
    P18066
    UniProtKB/TrEMBL
    A0A8C0R8Z7
    Conserved Domains (1) summary
    cd01860
    Location:20 → 182
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    23790486..23820520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038431587.1 → XP_038287515.1  ras-related protein Rab-5A isoform X1

    UniProtKB/Swiss-Prot
    P18066
    UniProtKB/TrEMBL
    A0A8C0R8Z7
    Related
    ENSCAFP00845029329.1, ENSCAFT00845037438.1
    Conserved Domains (1) summary
    cd01860
    Location:20 → 182
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    23503982..23531284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    23569385..23596703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    23815500..23842853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23330152..23357439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18066.1 GenPept UniProtKB/Swiss-Prot:P18066

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.